Obesity and Insulin Resistance Are Inversely Associated with Serum and Adipose Tissue Carotenoid Concentrations in Adults
| Autor: | Ayelet Harari, Jerry R. Greenfield, Adelle C.F. Coster, Dror Harats, Aviv Shaish, Arthur B. Jenkins, Aimin Xu, Dorit Samocha-Bonet |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine obesity medicine.medical_specialty Lutein Medicine (miscellaneous) Adipose tissue 030209 endocrinology & metabolism serum carotenoids 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Phytoene Insulin resistance Risk Factors insulin resistance Internal medicine Biopsy medicine Humans Carotenoid chemistry.chemical_classification 030109 nutrition & dietetics Nutrition and Dietetics medicine.diagnostic_test business.industry carotenoids Retinol food and beverages Middle Aged medicine.disease Phytofluene Glucose Endocrinology Adipose Tissue Gene Expression Regulation chemistry Cytokines Female Nutrient Physiology Metabolism and Nutrient-Nutrient Interactions adipose tissue carotenoids business dietary carotene retinol |
| Zdroj: | The Journal of Nutrition |
| ISSN: | 0022-3166 |
| DOI: | 10.1093/jn/nxz184 |
| Popis: | Background Low tissue concentrations of carotenoids have been suggested to contribute to insulin resistance in obesity. Objectives The objectives of the study were to 1) evaluate the relations of adipose tissue and serum carotenoids with body fat, abdominal fat distribution, muscle, adipose tissue and liver insulin resistance, and dietary intake; 2) evaluate the relations and distributions of carotenoids detected in adipose tissue and serum; and 3) compare serum carotenoids and retinol concentrations in subjects with and without obesity. Methods Post hoc analysis of serum and adipose tissue carotenoids in individuals [n = 80; 31 men, 49 women; age (mean ± SEM): 51.4 ± 1.1 y] who participated in 2 separate studies conducted at the Clinical Research Facility at the Garvan Institute of Medical Research (Sydney) between 2008 and 2013. Retinol, α-carotene, β-carotene, ζ-carotene, lutein, lycopene, phytoene, and phytofluene were measured using HPLC. Body composition was measured by dual-energy X-ray absorptiometry. Insulin resistance was measured by 2-step hyperinsulinemic-euglycemic clamps with deuterated glucose (n = 64), and subcutaneous and visceral abdominal volume and liver and pancreatic fat by MRI (n = 60). Periumbilical subcutaneous fat biopsy was performed and carotenoids and retinol measured in the tissue (n = 16). Results We found that ζ-carotene, phytoene, and phytofluene were stored in considerable amounts in adipose tissue (25% of adipose tissue carotenoids). Carotenoid concentrations in adipose tissue and serum correlated significantly, but they followed different distributions: ζ-carotene was 3-fold higher in adipose tissue compared with serum, while lutein and lycopene made up 20% and 21% of serum carotenoids compared with 2% and 12% of adipose tissue carotenoids, respectively. Liver (P ≤ 0.028) and adipose tissue (P = 0.023), but not muscle (P ≥ 0.16), insulin resistance correlated inversely with many of the serum carotenoids. Conclusions Multiple serum and adipose tissue carotenoids are associated with favorable metabolic traits, including insulin sensitivity in liver and adipose tissue in humans. |
| Databáze: | OpenAIRE |
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