Differentiation of Urothelial Carcinoma and Normal Bladder Tissues by Means of Fiber-Based ATR IR Spectroscopy

Autor: Rimantė Bandzevičiūtė, Gediminas Platkevičius, Justinas Čeponkus, Arūnas Želvys, Albertas Čekauskas, Valdas Šablinskas
Rok vydání: 2023
Předmět:
Zdroj: Cancers; Volume 15; Issue 2; Pages: 499
Cancers, Basel : MDPI, 2023, vol. 15, no. 2, art. no. 499, p. [1-12]
ISSN: 2072-6694
DOI: 10.3390/cancers15020499
Popis: Non-muscle-invasive bladder cancer (NMIBC) is a complicated locally treated disease with high recurrence rates and high risk of progression to muscle invasive disease. Current standard diagnostic approach based on white light cystoscopy (WLC) is characterized by high false negative rate, excessive invasion of the bladder and high economic burden. Hereby we present the fiber-based attenuated total reflection infrared (ATR IR) spectroscopy study of healthy and cancerous tissue samples taken from 54 patients to delineate normal and tumorous human bladder tissues under ex vivo conditions. Investigation of the tissue samples immediately after surgical operation allows to examine samples in their native conditions and establish their initial structure and chemical composition avoiding sample degradation. Our study reveals that fiber-based ATR IR spectroscopy could be an addition to current endoscopic approach with increased diagnostic accuracy and with some potential to be applied in vivo.
Databáze: OpenAIRE
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