Antifungal activity of interleukin-2-activated natural killer (NK1.1+) lymphocytes against Candida albicans
| Autor: | Linda Witek-Janusek, Herbert L. Mathews |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Microbiology (medical)
Interleukin 2 CD8 Antigens medicine.medical_treatment Biology Microbiology Natural killer cell Interferon-gamma Mice Interferon Candida albicans medicine Animals Interferon gamma Cells Cultured Mice Inbred BALB C Antibodies Monoclonal Complement System Proteins General Medicine biology.organism_classification Yeast Corpus albicans Killer Cells Natural Cytokine medicine.anatomical_structure Culture Media Conditioned Interleukin-2 Female Spleen medicine.drug |
| Zdroj: | Journal of Medical Microbiology. 47:1007-1014 |
| ISSN: | 1473-5644 0022-2615 |
| Popis: | Interleukin-2 (IL-2)-activated lymphocytes interact directly with, and inhibit, the growth of Candida albicans hyphae. C. albicans-stimulated natural killer (NK1.1+) lymphocytes were demonstrated to secrete a soluble product capable of directly affecting C. albicans yeast forms. Antibodies specific for interferon-gamma completely eliminated the antifungal activity of the NK1.1+ lymphocyte product and diminished the antifungal activity of NK1.1+ lymphocytes against C. albicans. Antibodies specific for other cytokines had no such effect. These data demonstrate that C. albicans-stimulated NK1.1+ lymphocytes have antifungal activity against C. albicans yeast cells via the release of interferon-gamma. This antifungal activity was demonstrable only against the yeast form of the fungus, with no effect on C. albicans hyphae. |
| Databáze: | OpenAIRE |
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