Clinical screening and identification of sarcopenic obesity in adults with advanced knee osteoarthritis
| Autor: | Linda J. Woodhouse, Kristine Godziuk, Mary Forhan, Carla M. Prado |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Sarcopenia Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Osteoarthritis Logistic regression 03 medical and health sciences Grip strength 0302 clinical medicine medicine Humans Sarcopenic obesity Obesity Aged 2. Zero hunger 030109 nutrition & dietetics Nutrition and Dietetics Receiver operating characteristic business.industry Area under the curve Osteoarthritis Knee medicine.disease Cross-Sectional Studies Physical therapy Quality of Life Female business Body mass index |
| Zdroj: | Clinical nutrition ESPEN. 40 |
| ISSN: | 2405-4577 |
| Popis: | Summary Background and aims Sarcopenic obesity (defined as low muscle mass and strength with high adiposity) requires attention in adults with advanced knee osteoarthritis (OA) due to implications on treatment outcomes. This study aimed to identify muscle function measures and patient characteristics associated with the presence of low muscle mass that could be used to screen and detect sarcopenic obesity in patients with knee OA in the clinical setting. Methods Cross-sectional study of patients with knee OA and a body mass index (BMI) ≥30 kg/m2. Body composition was measured in n = 151 patients (59% female, mean age 65.1 ± 7.9 years) using dual-energy x-ray absorptiometry. Appendicular skeletal muscle mass (ASM) adjusted by BMI and below established sex-specific cut-points was used to differentiate low muscle mass. Muscle function was assessed by 4-m gait speed, 6 min walk test, and maximal grip strength (absolute, and relative, adjusted by BMI). Logistic regression was used to assess the relationship between muscle function measures, patient characteristics, and low muscle mass. Receiver operating characteristic curves and area under the curve (AUC) were used to examine the final model and identify potential clinical cut-points. Results Sex and relative grip strength were associated with low muscle mass (AUC 0.774, p Conclusion Relative grip strength shows promise as a clinical screening measure for sarcopenic obesity in patients with knee OA. |
| Databáze: | OpenAIRE |
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