Long-term metabolic effects of malnutrition: Liver steatosis and insulin resistance following early-life protein restriction
| Autor: | Rose Chami, Nathan Swain, Ling Zhang, Steven Yang, Senjuti Saha, Robert H. J. Bandsma, Celine Bourdon, Junsoo Kim, Prasad S. Dalvi |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Steatosis Low protein Physiology medicine.medical_treatment lcsh:Medicine Pathology and Laboratory Medicine Cytopathology Mice Endocrinology 0302 clinical medicine Non-alcoholic Fatty Liver Disease Medicine and Health Sciences 030212 general & internal medicine lcsh:Science Immune Response Multidisciplinary Liver Diseases Fatty liver Animal Models Type 2 Diabetes Experimental Organism Systems Physiological Parameters Female Research Article Endocrine Disorders Immunology Mouse Models Gastroenterology and Hepatology Research and Analysis Methods Protein-Energy Malnutrition 03 medical and health sciences Model Organisms Signs and Symptoms Insulin resistance Low-protein diet Diagnostic Medicine Glucose Intolerance Diet Protein-Restricted Diabetes Mellitus medicine Animals Weaning Obesity Nutrition Inflammation business.industry Insulin lcsh:R Malnutrition Body Weight Biology and Life Sciences medicine.disease Diet Mice Inbred C57BL Fatty Liver Glucose 030104 developmental biology Diet and Type 2 Diabetes Anatomical Pathology Metabolic Disorders lcsh:Q Insulin Resistance business |
| Zdroj: | PLoS ONE PLoS ONE, Vol 13, Iss 7, p e0199916 (2018) |
| ISSN: | 1932-6203 |
| Popis: | Early postnatal-life malnutrition remains prevalent globally, and about 45% of all child deaths are linked to malnutrition. It is not clear whether survivors of childhood malnutrition suffer from long-term metabolic effects, especially when they are later in life exposed to a fat and carbohydrate rich obesogenic diet. The lack of knowledge around this dietary "double burden" warrants studies to understand the long-term consequences of children previously exposed to malnutrition. We hypothesized that an early-life nutritional insult of low protein consumption in mice would lead to long-term metabolic disturbances that would exacerbate the development of diet-induced insulin resistance and non-alcoholic fatty liver disease (NAFLD). We investigated the effects of feeding a low protein diet (4% wt/wt) immediately after weaning for four weeks and subsequent feeding of a high carbohydrate high fat feeding for 16 weeks on metabolic function and development of NAFLD. Mice exposed to early-life protein restriction demonstrated a transient glucose intolerance upon recovery by regular chow diet feeding. However, protein restriction after weaning in mice did not exacerbate an obesogenic diet-induced insulin resistance or progression to NAFLD. These data suggest that transient protein restriction in early-life does not exacerbate an obesogenic diet-induced NAFLD and insulin resistance. |
| Databáze: | OpenAIRE |
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