Dependency of Renal Blood Flow on Prostaglandin Synthesis in the Dog
| Autor: | John C. McGiff, Andrew J. Lonigro, Keith Crowshaw, Harold D. Itskovitz |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Male
medicine.medical_specialty Cardiac output Physiology Indomethacin Anti-Inflammatory Agents Blood Pressure Arachidonic Acids Kidney chemistry.chemical_compound Dogs Equivalent Internal medicine medicine Animals Bioassay ortho-Aminobenzoates Carbon Isotopes Chromatography Venous blood Blood flow Perfusion Endocrinology chemistry Regional Blood Flow Renal blood flow Prostaglandins Arachidonic acid Efflux Cardiology and Cardiovascular Medicine Toluene |
| Zdroj: | Circulation Research. 32:712-717 |
| ISSN: | 1524-4571 0009-7330 |
| DOI: | 10.1161/01.res.32.6.712 |
| Popis: | Inhibition of prostaglandin synthesis in chloralose-anesthetized dogs reduced renal blood flow, and this reduction closely correlated (r=0.92, P 2 . We used solvent extraction and thin-layer chromatography coupled with parallel bioassay to identify and assay the PGE- and PGF-like substances (expressed as PGE 2 and PGF 2α equivalents). Either of two antiinflammatory acids, indomethacin or meclofenamate, that inhibited conversion of 14 C-arachidonic acid to prostaglandins in renal homogenates decreased the basal concentration of a PGE-like substance in renal venous blood to 0.06 ± 0.02 ng/ml from a mean control value of 0.34 ± 0.10 ng/ml ( P 2 participates in maintaining renal vascular tone which heretofore has been ascribed to autonomous, intrinsic renal arteriolar activity. |
| Databáze: | OpenAIRE |
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