Predictors for recurrent/persistent high-grade intraepithelial lesions and cervical stenosis after therapeutic conization: a retrospective analysis of 522 cases
| Autor: | Akiko Okazawa, Yusuke Tanaka, Satoshi Kubota, Tadashi Kimura, Kae Hashimoto, Shinya Matsuzaki, Satoko Matsuzaki, Kiyoshi Yoshino, Takuji Tomimatsu, Eiji Kobayashi, Tadashi Iwamiya, Yutaka Ueda, Mamoru Kakuda, Kenjiro Sawada, Seiji Mabuchi |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Surgical margin medicine.medical_treatment Conization Uterine Cervical Neoplasms Constriction Pathologic Logistic regression Cervical intraepithelial neoplasia 03 medical and health sciences 0302 clinical medicine Postoperative Complications Risk Factors Internal medicine medicine Odds Ratio Humans Aged Proportional Hazards Models Retrospective Studies Hematometra Aged 80 and over 030219 obstetrics & reproductive medicine Hysterectomy business.industry Hazard ratio Hematology General Medicine Odds ratio Middle Aged medicine.disease Uterine Cervical Dysplasia Surgery Stenosis Logistic Models Oncology 030220 oncology & carcinogenesis Female Neoplasm Recurrence Local business Follow-Up Studies |
| Zdroj: | International journal of clinical oncology. 22(5) |
| ISSN: | 1437-7772 |
| Popis: | The objective of the study is to identify the risk factors associated with recurrent/persistent disease and cervical stenosis after conization. Five hundred twenty-two (522) cases of high-grade intraepithelial lesions treated by conization were retrospectively reviewed. Risk factors associated with recurrent/persistent disease were analyzed by univariate and multivariate analysis using a Cox hazard regression model. Factors that could potentially affect the risk of cervical stenosis were examined by univariate and by multivariate analysis using the χ 2 test and logistic regression, respectively. Recurrent/persistent diseases and cervical stenosis occurred in 4.8% and 5.4% of the patients, respectively. Age ≥46 years [hazard ratio (HR) 3.6, 95% CI 1.36–10.3, p = 0.0092] and surgical margin involvement (HR 13.44, 95% CI 5.07–46.37, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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