Transforming Growth Factor Beta Mediates the Estrogen Induced Inhibition of Umr106 Cell Growth
| Autor: | T. K. Gray, T. Linkhart, Barbara D. Lipes, D. Baylink, S. Mohan |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
medicine.medical_specialty
TGF alpha medicine.drug_class medicine.medical_treatment Monoclonal antibody Biochemistry Rheumatology Internal medicine Tumor Cells Cultured medicine Animals Orthopedics and Sports Medicine Molecular Biology Osteosarcoma Osteoblasts Estradiol biology Cell growth Chemistry Insulin Estrogens Cell Biology Transforming growth factor beta Alkaline Phosphatase Rats Endocrinology Estrogen Transforming Growth Factors biology.protein Alkaline phosphatase Cell Division Transforming growth factor |
| Zdroj: | Connective Tissue Research. 20:23-32 |
| ISSN: | 1607-8438 0300-8207 |
| DOI: | 10.3109/03008208909023871 |
| Popis: | A mitogenic response to transforming growth factor beta (TGF) occurred in the UMR106 cells cultured in serum-free medium and exposed serially to estradiol and TGF. This mitogenic response was lost when insulin was removed from the medium. TGF inhibited growth and increased the alkaline phosphatase content in the UMR106 cells cultured in medium lacking insulin. Prior exposure of the cells to estradiol enhanced this response. Monoclonal antibodies against TGF blocked the estradiol induced inhibition of growth after a two day incubation in medium devoid of insulin. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|