A comprehensive review of the multifaceted role of the microbiota in human pancreatic carcinoma
| Autor: | Arul Goel, Amit Kumar Pandey, Aishwarya Singh, Manoj Garg, Gautam Sethi, Kanchugarakoppal S. Rangappa, Simran Tandon, Chakrabhavi Dhananjaya Mohan, Gouri Pandya, Anuradha Kirtonia, Sonia Kapoor |
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| Rok vydání: | 2022 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_treatment Antineoplastic Agents Bioinformatics digestive system 03 medical and health sciences 0302 clinical medicine Immune system Quality research Pancreatic cancer Tumor Microenvironment Humans Medicine Microbiome Pancreatic carcinoma Tumor microenvironment business.industry Mechanism (biology) Microbiota Immunotherapy medicine.disease Gastrointestinal Microbiome Pancreatic Neoplasms stomatognathic diseases 030104 developmental biology 030220 oncology & carcinogenesis business |
| Zdroj: | Seminars in Cancer Biology. 86:682-692 |
| ISSN: | 1044-579X |
| Popis: | Pancreatic carcinoma is associated with one of the worst clinical outcomes throughout the globe because of its aggressive, metastatic, and drug-resistant nature. During the past decade, several studies have shown that oral, gut, and tumor microbiota play a critical role in the modulation of metabolism and immune responses. Growing pieces of evidence have proved beyond a doubt that the microbiota has a unique ability to influence the tumor microenvironment as well as the metabolism of chemotherapeutic agents or drugs. Given this, microbiota, known as the ecological community of microorganisms, stands to be an avenue of quality research. In this review, we provide detailed and critical information on the role of oral, gut, and pancreatic microbiota disruptions in the development of pancreatic carcinoma. Moreover, we comprehensively discuss the different types of microbiota, their potential role, and mechanism associated with pancreatic carcinoma. The microbiome provides the unique opportunity to enhance the effectiveness of chemotherapeutic agents and immunotherapies for pancreatic cancer by maintaining the right type of microbiota and holds a promising future to enhance the clinical outcomes of patients with pancreatic carcinoma. |
| Databáze: | OpenAIRE |
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