The Effects of Pyromen Administered Intravenously in Subpyrexial Doses to Depressed Patients

Autor:	Annette C. Washburne, Edna M. J. Fitch
Rok vydání:	1951
Předmět:	Depressive Disorder biology Depression business.industry medicine.medical_treatment Polysaccharides Bacterial Proteus vulgaris Hyperthermia Induced General Medicine Pharmacology biology.organism_classification Fever therapy Stimulant Toxicity Humans Medicine business Saline Clinical evaluation
Zdroj:	New England Journal of Medicine. 245:961-966
ISSN:	1533-4406 0028-4793
DOI:	10.1056/nejm195112202452502
Popis:	PYROMEN is a sterile, nonprotein, nonana-phylactogenic extract of Pseudomonas aemginosa and Proteus vulgaris prepared as a colloidal dispersion in normal saline for intravenous use.1 , 2 Pharmacologically, it is a pyrogen of a high degree of reliability and a low order of toxicity. Chemical analysis has identified it as a complex polysaccharide.1 2 3 4 Study of the histologie and physiologic effects in animals revealed some ACTH-like effects.3 4 5 6 Clinical evaluation was directed toward its efficacy not only as a pyrexial agent but also as a stimulant of the pituitary-adrenal axis in those diseases believed to respond to ACTH.7 8 9 10 11 In certain allergic states it proved beneficial . . .
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ed5a0c43b2d6d8af006e120bc6248db https://doi.org/10.1056/nejm195112202452502 Zobrazit plný text záznamu