Dibenzocyclooctadiene lignans from Kadsura heteroclita
Autor: | Miao Liu, Kun Hu, Yuan-Qing Luo, Han-Dong Sun, Wei-Guang Wang, Xiao-Nian Li, Jin Wen, Xue Du, Jian-Xin Pu |
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Rok vydání: | 2017 |
Předmět: |
Stereochemistry
HL-60 Cells Nitric Oxide 01 natural sciences Lignans Cyclooctanes Mice chemistry.chemical_compound Kadsura Cell Line Tumor Drug Discovery Animals Humans Pharmacology Natural product Molecular Structure Plant Stems 010405 organic chemistry Chemistry Macrophages Absolute configuration General Medicine 0104 chemical sciences 010404 medicinal & biomolecular chemistry RAW 264.7 Cells Kadsura heteroclita |
Zdroj: | Fitoterapia. 119:150-157 |
ISSN: | 0367-326X |
DOI: | 10.1016/j.fitote.2017.04.013 |
Popis: | Sixteen dibenzocyclooctadiene lignans, including eight new ones, kadheterins A-H (1-8), and a new natural product, 9-benzoyloxy-gomisin B (9), were isolated from the stems of K. heteroclita. The structures of 1-9 were elucidated by extensive spectroscopic methods, and their absolute configurations were determined by combining CD with ROESY experiments. Additionally, the absolute configuration of 1 was further confirmed by single crystal X-ray crystallographic analysis. In vitro activity assays showed that 1 exhibited moderate cytotoxicity against HL-60 with IC50 value at 14.59μM. |
Databáze: | OpenAIRE |
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