Dibenzocyclooctadiene lignans from Kadsura heteroclita

Autor: Miao Liu, Kun Hu, Yuan-Qing Luo, Han-Dong Sun, Wei-Guang Wang, Xiao-Nian Li, Jin Wen, Xue Du, Jian-Xin Pu
Rok vydání: 2017
Předmět:
Zdroj: Fitoterapia. 119:150-157
ISSN: 0367-326X
DOI: 10.1016/j.fitote.2017.04.013
Popis: Sixteen dibenzocyclooctadiene lignans, including eight new ones, kadheterins A-H (1-8), and a new natural product, 9-benzoyloxy-gomisin B (9), were isolated from the stems of K. heteroclita. The structures of 1-9 were elucidated by extensive spectroscopic methods, and their absolute configurations were determined by combining CD with ROESY experiments. Additionally, the absolute configuration of 1 was further confirmed by single crystal X-ray crystallographic analysis. In vitro activity assays showed that 1 exhibited moderate cytotoxicity against HL-60 with IC50 value at 14.59μM.
Databáze: OpenAIRE