Donor scoring system for heart transplantation and the impact on patient survival
| Autor: | Jacqueline M. Smits, Guenther Laufer, Andreas Zuckermann, Erwin de Vries, Bruno Meiser, Axel Rahmel, Michel De Pauw |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Graft Rejection Male Pulmonary and Respiratory Medicine medicine.medical_specialty Tissue and Organ Procurement medicine.medical_treatment Comorbidity Malignancy Risk Assessment Cohort Studies Sepsis Cause of Death Internal medicine Diabetes mellitus medicine Humans Aged Retrospective Studies Cause of death Heart transplantation Transplantation business.industry Age Factors Middle Aged Prognosis medicine.disease Tissue Donors Surgery Europe Logistic Models Treatment Outcome Heart Transplantation Female Dobutamine Cardiology and Cardiovascular Medicine business Risk assessment Body mass index medicine.drug |
| Zdroj: | The Journal of Heart and Lung Transplantation. 31:387-397 |
| ISSN: | 1053-2498 |
| Popis: | The aim of this study was to design and validate a heart donor score that reflects experts' perceived risk of allograft failure.All heart donors reported to Eurotransplant between January 1, 2005 and December 31, 2008 (N = 4,110) were used to create a donor score. Based on observed discard rates and using multivariate regression, points were assigned for the following donor factors: age; cause of death; body mass index (BMI); diabetes mellitus (DM); duration of ICU stay; compromised history (drug, abuse, sepsis, meningitis, malignancy, HBsAg(+) or anti-HCV(+)); hypertension; cardiac arrest; echocardiography; coronary angiogram; serum sodium; and noradrenaline and dopamine/dobutamine doses. The donor score was obtained by adding all points. All heart donors reported to Eurotransplant in 2009 were included to validate the score (N = 885).All donor factors, except BMI, DM and duration of ICU stay, significantly predicted discard. Based on the median value of the score, donors were classified into low-risk donors (LRDs: ≤16 points) and high-risk donors (HRDs: ≥17 points). In the validation set, discard rates were significantly different when comparing HRDs (35%) and LRDs (7%) (p0.0001). In addition, the heart donor score was significantly associated with 3-year survival: LRD 81.5% vs HRD 70.0% (p = 0.004).The heart donor score accurately reflects the likelihood of organ acceptance and predicts long-term patient mortality. Application of this score at time of donor reporting may facilitate donor risk assessment and allow for more appropriate matching of extended criteria donor hearts. |
| Databáze: | OpenAIRE |
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