Concussion increases CA1 activity during prolonged inactivity in a familiar environment
| Autor: | Andrea Nam, Shanti R. Tummala, David F. Meaney, Matthew A. Hemphill |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Environment Hippocampal formation Article Open field Blast injury Mice 03 medical and health sciences 0302 clinical medicine Developmental Neuroscience Concussion medicine Animals Wakefulness CA1 Region Hippocampal Brain Concussion business.industry Recognition Psychology Cognition medicine.disease Familiar environment Mice Inbred C57BL 030104 developmental biology Neurology Exploratory Behavior Home cage Sedentary Behavior business Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Exp Neurol |
| ISSN: | 0014-4886 |
| Popis: | Although hippocampal damage plays a key role in impairments after concussion, differences in hippocampal information processing during recovery are unknown. Micro-endoscopic calcium imaging was performed before and after primary blast injury in freely behaving mice in two environments: their familiar home cage and a novel open field. Results show that after concussion CA1 activity increased in the familiar environment in which animals were awake and mostly immobile but was unaltered in a novel environment which the animals actively and constantly explored. As awake immobility parallels cognitive rest, a common treatment for patients, the results imply that prolonged cognitive rest may unwittingly impede concussion recovery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect