Response of lymphoid leukemia L1210 in mice to implantable sustained release cytosine arabinoside capsules

Autor: J. C. Fu, D. L. Moyer, D. Elshire, Tasneem A. Khwaja, J. Varvan, L. Cummings
Rok vydání: 1978
Předmět:
Zdroj: Journal of Surgical Oncology. 10:1-7
ISSN: 1096-9098
0022-4790
DOI: 10.1002/jso.2930100102
Popis: The lifespan of BDF mice with ascitic L1210 leukemia is more than doubled when they are treated with a single subcutaneously or intraperitoneally implanted sustained release cytosine arabinoside capsule. These capsules are drug-polymer composites, with dimensions of 1.0 cm in diameter and 0.15 cm in thickness, and a drug content of 17 +/- 3 mg each. Blank silicone rubber discs implanted intraperitoneally or subcutaneously in the leukemic mice produced no beneficial effects. Control healthy mice receiving the ARA-C releasing capsules continued to live with no obvious signs of drug toxicity. In vitro release of ARA-C from the discs was measured. Drug release was maintained above 20 micrograms per day for more than 35 days. ARA-C extracted from discs recovered from implant studies showed that less than 16% of the total drug content was released in vivo.
Databáze: OpenAIRE