Induction of antigen-specific cytotoxic T lymphocytes in humans by a malaria DNA vaccine
| Autor: | Ruobing Wang, Kevin M. Coonan, Jon Norman, Walter R. Weiss, Thong P. Le, Stephen L. Hoffman, Martha Sedegah, Trevor R. Jones, Yupin Charoenvit, Jennifer Ng, Richard C. Hedstrom, Michal Margalith, Denise L. Doolan, Charles de Taisne, Peter Hobart |
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| Rok vydání: | 1998 |
| Předmět: |
Adult
Male T cell Plasmodium falciparum Protozoan Proteins Genes MHC Class I Antigens Protozoan Human leukocyte antigen DNA vaccination Antigen HLA Antigens MHC class I Malaria Vaccines medicine Vaccines DNA Cytotoxic T cell Animals Humans Immunization Schedule Multidisciplinary biology Vaccination T lymphocyte Virology medicine.anatomical_structure Immunology biology.protein Female CD8 T-Lymphocytes Cytotoxic |
| Zdroj: | Science (New York, N.Y.). 282(5388) |
| ISSN: | 0036-8075 |
| Popis: | CD8+cytotoxic T lymphocytes (CTLs) are critical for protection against intracellular pathogens but often have been difficult to induce by subunit vaccines in animals. DNA vaccines elicit protective CD8+T cell responses. Malaria-naı̈ve volunteers who were vaccinated with plasmid DNA encoding a malaria protein developed antigen-specific, genetically restricted, CD8+T cell–dependent CTLs. Responses were directed against all 10 peptides tested and were restricted by six human lymphocyte antigen (HLA) class I alleles. This first demonstration in healthy naı̈ve humans of the induction of CD8+CTLs by DNA vaccines, including CTLs that were restricted by multiple HLA alleles in the same individual, provides a foundation for further human testing of this potentially revolutionary vaccine technology. |
| Databáze: | OpenAIRE |
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