Lipid Analysis on Block Copolymer-containing Packaging Solution and Lens Care Regimens: A Randomized Clinical Trial
| Autor: | Christopher Lievens, Amanda Shows, Rachel L. Redfern, Jennifer Swingle Fogt, Jessie M Lemp-Hull, Loretta B Szczotka-Flynn, Sebastian Marx, Wolfgang Sickenberger, Anna A Tichenor, Marc M. Schulze, Stefan Schwarz |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty Silicones Alkenes law.invention Polyethylene Glycols 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Double-Blind Method law Ophthalmology Total cholesterol medicine Product Packaging Humans Fluorometry Prospective Studies business.industry Lotrafilcon B Hydrogels Silicone hydrogel Contact Lenses Hydrophilic Lens (optics) Alcon Laboratories Cholesterol Multicenter study Tears 030221 ophthalmology & optometry Silicone Elastomers Female Contact Lens Solutions business 030217 neurology & neurosurgery Optometry |
| Zdroj: | Optometry and vision science : official publication of the American Academy of Optometry. 97(8) |
| ISSN: | 1538-9235 |
| Popis: | SIGNIFICANCE Lotrafilcon B lenses packaged in and cared for with block copolymer-containing (polyoxyethylene-polyoxybutylene; EOBO) lens care solutions resulted in lower cholesterol extraction than each of the habitual silicone hydrogel lens/multipurpose solution (MPS) regimens tested. PURPOSE This study aimed to compare the extracted cholesterol of lotrafilcon B lenses packaged in and cared for with EOBO-containing lens care solutions with the extracted cholesterol of habitual silicone hydrogel lenses cared for with MPS not containing EOBO. METHODS In this prospective, randomized, observer-masked parallel study, habitual wearers of senofilcon C, senofilcon A, comfilcon A, and samfilcon A contact lenses using a non-EOBO MPS were randomized 1:1 to lotrafilcon B lenses packaged in and cared for with EOBO-containing solutions or to their habitual lenses and MPS. Subjects randomized to lotrafilcon B were further randomized to one of two EOBO-containing lens care solutions, OPTI-FREE PUREMOIST or CLEAR CARE PLUS with HydraGlyde (Alcon Laboratories, Inc., Fort Worth, TX). A subset of right eye lenses was collected after wear, and total cholesterol was extracted and measured using a fluorometric enzymatic assay. RESULTS Of 143 lenses analyzed, 95 were from subjects randomized to their habitual lenses/MPS and 48 to lotrafilcon B + EOBO lenses plus CLEAR CARE PLUS with HydraGlyde or OPTI-FREE PUREMOIST. The mean amounts of cholesterol extracted from lotrafilcon B + EOBO lenses cared for with CLEAR CARE PLUS with HydraGlyde (0.28 ± 0.18 μg/lens) and OPTI-FREE PUREMOIST (0.28 ± 0.48 μg/lens) were significantly lower than those extracted from senofilcon C (4.18 ± 3.25 μg/lens), senofilcon A (2.19 ± 2.69 μg/lens), comfilcon A (2.17 ± 1.47 μg/lens), and samfilcon A (2.07 ± 1.48 μg/lens) lenses used with MPS (P < .0001 each). CONCLUSIONS Cholesterol sorption was significantly lower in wearers of lotrafilcon B lenses cared for with polyoxyethylene-polyoxybutylene-containing lens care solutions than in users of habitual silicone hydrogel lenses cared for with non-polyoxyethylene-polyoxybutylene MPS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|