Field Evaluation of a Dual Rapid Immunodiagnostic Test for HIV and Syphilis Infection in Peru
| Autor: | Juan A Flores, Lourdes B. Ramos, Kelika A. Konda, Emily Huang, Carlos F. Caceres, Silver K. Vargas, Jeffrey D. Klausner, Segundo R. Leon, Claire C. Bristow |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Treponema pallidum/immunology Syphilis/diagnosis Human immunodeficiency virus (HIV) HIV Infections HIV Antibodies medicine.disease_cause Immunoenzyme Techniques 0302 clinical medicine Peru 030212 general & internal medicine Young adult Treponema medicine.diagnostic_test biology purl.org/pe-repo/ocde/ford#3.02.15 [https] Antibodies Bacterial Test (assessment) HIV Infections/diagnosis Infectious Diseases Female Antibody 0305 other medical science Adult Microbiology (medical) medicine.medical_specialty Adolescent Point-of-Care Systems Dermatology Sensitivity and Specificity Transgender Persons Article Young Adult 03 medical and health sciences Internal medicine Confidence Intervals medicine Humans Syphilis Treponema pallidum Homosexuality Male Antibodies Bacterial/immunology Sex Workers 030505 public health business.industry Public Health Environmental and Occupational Health medicine.disease biology.organism_classification Confidence interval Immunoassay Immunology biology.protein HIV Antibodies/immunology Reagent Kits Diagnostic business Peru/epidemiology |
| Zdroj: | Sexually Transmitted Diseases. 43:57-60 |
| ISSN: | 0148-5717 |
| DOI: | 10.1097/olq.0000000000000387 |
| Popis: | BACKGROUND: Integrated prevention for HIV and syphilis is warranted because both syphilis and HIV infections have evidence-based, scalable interventions using current health care mechanisms. The advent of dual rapid point-of-care tests, single devices that can detect multiple infections using the same specimen, provides the opportunity to integrate the screening of syphilis into HIV prevention programs, potentially increasing the numbers of people tested and allowing for same-day testing and treatment. The aim of our study was to evaluate the MedMira Multiplo Rapid TP/HIV Antibody Test (MedMira Inc, Halifax, Nova Scotia, Canada), a qualitative, rapid immunoassay that detects antibodies to Treponema pallidum and HIV. METHODS: The reference test for comparison to the T. pallidum component of the Multiplo TP/HIV Test was the T. pallidum particle agglutination assay. For the HIV component, the reference test included a fourth-generation enzyme immunoassay with a confirmatory Western blot test. RESULTS: The sensitivity and specificity for the HIV antibody component were 93.8% (95% confidence interval [CI], 69.8%-99.8%) and 100% (95% CI, 97.7%-100%), respectively. The T. pallidum component of the test had a sensitivity of 81.0% (95% CI, 68.1%-94.6%) and a specificity of 100% (95% CI, 97.6%-100%). CONCLUSIONS: Our study showed excellent performance of the HIV antibody component of the test and very good performance for the T. pallidum antibody component of the MedMira Multiplo Rapid TP/HIV Antibody Test, which should be considered to improve screening coverage. Use of effective dual tests will create improved access to more comprehensive care by integrating the screening of syphilis into HIV prevention programs. |
| Databáze: | OpenAIRE |
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