Methylene blue as an antimalarial agent
| Autor: | R. Heiner Schirmer, Olaf Müller, Wolfgang Schiek, Bocar Kouyaté, Heiko Becher, Katja Becker, Boubacar Coulibaly, Thomas Zich, Jana Eubel, August Stich, Michael Scheiwein, Heiko Merkle |
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| Rok vydání: | 2004 |
| Předmět: |
Physiology
Clinical Biochemistry Glutathione reductase Plasmodium falciparum Biology Pharmacology Methemoglobinemia Biochemistry chemistry.chemical_compound Antimalarials Chloroquine parasitic diseases medicine Animals Humans Antimalarial Agent Malaria Falciparum Clinical Trials as Topic Biochemistry (medical) Cell Biology Glutathione medicine.disease biology.organism_classification Antiparasitic agent Methylene Blue Glutathione Reductase chemistry Oxidation-Reduction Methylene blue medicine.drug |
| Zdroj: | Redox report : communications in free radical research. 8(5) |
| ISSN: | 1351-0002 |
| Popis: | Methylene blue has intrinsic antimalarial activity and it can act as a chloroquine sensitizer. In addition, methylene blue must be considered for preventing methemoglobinemia, a serious complication of malarial anemia. As an antiparasitic agent, methylene blue is pleiotropic: it interferes with hemoglobin and heme metabolism in digestive organelles, and it is a selective inhibitor of Plasmodium falciparum glutathione reductase. The latter effect results in glutathione depletion which sensitizes the parasite for chloroquine action. At the Centre de Recherche en Sante de Nouna in Burkina Faso, we study the combination of chloroquine with methylene blue (BlueCQ) as a possible medication for malaria in endemic regions. A pilot study with glucose-6-phosphate dehydrogenase-sufficient adult patients has been conducted recently. |
| Databáze: | OpenAIRE |
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