IL‐34 and CSF‐1, deciphering similarities and differences at steady state and in diseases
Autor: | Apolline Salama, Antoine Freuchet, Ignacio Anegon, Carole Guillonneau, Séverine Remy |
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Přispěvatelé: | UMR1064,ITUN, Transgénèse Rat et ImmunoPhénomique, IBiSA / Biogenouest, Institut National de la Santé et de la Recherche Médicale (INSERM) |
Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
0301 basic medicine
Myeloid Immunology Phosphatase Receptor Macrophage Colony-Stimulating Factor Biology medicine.disease_cause Autoimmunity 03 medical and health sciences 0302 clinical medicine medicine Immunology and Allergy Animals Humans Disease Receptor ComputingMilieux_MISCELLANEOUS Clinical Trials as Topic Monocyte Interleukins Macrophage Colony-Stimulating Factor Cell Biology Epithelium 3. Good health Cell biology Transplantation 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis [SDV.IMM]Life Sciences [q-bio]/Immunology Intracellular |
Zdroj: | Journal of Leukocyte Biology Journal of Leukocyte Biology, Society for Leukocyte Biology, 2021, 110 (4), pp.771-796. ⟨10.1002/JLB.3RU1120-773R⟩ |
ISSN: | 0741-5400 |
Popis: | Although IL-34 and CSF-1 share actions as key mediators of monocytes/macrophages survival and differentiation, they also display differences that should be identified to better define their respective roles in health and diseases. IL-34 displays low sequence homology with CSF-1 but has a similar general structure and they both bind to a common receptor CSF-1R, although binding and subsequent intracellular signaling shows differences. CSF-1R expression has been until now mainly described at a steady state in monocytes/macrophages and myeloid dendritic cells, as well as in some cancers. IL-34 has also 2 other receptors, protein-tyrosine phosphatase zeta (PTPζ) and CD138 (Syndecan-1), expressed in some epithelium, cells of the central nervous system (CNS), as well as in numerous cancers. While most, if not all, of CSF-1 actions are mediated through monocyte/macrophages, IL-34 has also other potential actions through PTPζ and CD138. Additionally, IL-34 and CSF-1 are produced by different cells in different tissues. This review describes and discusses similarities and differences between IL-34 and CSF-1 at steady state and in pathological situations and identifies possible ways to target IL-34, CSF-1, and its receptors. |
Databáze: | OpenAIRE |
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