Outcomes of the national programme on prevention of mother-to-child transmission of hepatitis B virus in China, 2016–2017

Autor: Xiaoyan Wang, Yao Song, Xiao-Na Huang, Guo-Min Zhang, Yu-Ning Yang, Katrina Hann, Zhen Li, Lixia Dou, Xi Jin, Yaping Qiao, Yan-Lin Li, Ailing Wang, Min Su, Qian Wang
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Adult
medicine.medical_specialty
HBsAg
China
Hepatitis B virus
Hepatitis B vaccine
Birth weight
030231 tropical medicine
Enzyme-Linked Immunosorbent Assay
Perinatal
medicine.disease_cause
lcsh:Infectious and parasitic diseases
03 medical and health sciences
Young Adult
0302 clinical medicine
Immunization
elimination
medicine
Humans
lcsh:RC109-216
030212 general & internal medicine
Hepatitis B Antibodies
Hepatitis B Surface Antigens
Obstetrics
business.industry
lcsh:Public aspects of medicine
Public Health
Environmental and Occupational Health
Infant
virus diseases
lcsh:RA1-1270
General Medicine
Odds ratio
Hepatitis B
medicine.disease
Infectious Disease Transmission
Vertical
Vaccination guideline
Low birth weight
Infectious Diseases
Cross-Sectional Studies
HBeAg
Communicable Disease Control
Birth dose
medicine.symptom
business
Research Article
Zdroj: Infectious Diseases of Poverty, Vol 8, Iss 1, Pp 1-11 (2019)
Infectious Diseases of Poverty
ISSN: 2049-9957
Popis: Background In addition to providing free hepatitis B vaccine (HBvacc) series to all infants in China since 2005, the national programme on prevention of mother-to-child transmission (PMTCT) of hepatitis B virus (HBV) started providing free hepatitis B immunoglobulin for all new-borns born to hepatitis B surface-antigen (HBsAg) positive mothers in 2010. However, few studies have evaluated the effectiveness of the PMTCT programme. Therefore, we aimed to investigate the outcomes of the programme and identify associated factors. Method Using a cross-sectional study design, we collected data on 4112 pairs of HBsAg-positive mothers and their children aged 7–22 months in four representative provinces through interviews and medical record review. We tested HBsAg and hepatitis B surface antibody (anti-HBs) of children by enzyme-linked immunosorbent assay at designated maternal and child hospital laboratories. We used logistic regression to analyse factors associated with child HBsAg and anti-HBs positivity. Results Thirty-five children were HBsAg positive, indicating the mother-to-child transmission (MTCT) rate was 0.9% (0.6–1.1%). The anti-HBs positive rate was 96.8% (96.3-97.4%). Children receiving HBvacc between 12 and 24 h of birth were 2.9 times more likely to be infected than those vaccinated in less than 12 h (adjusted odds ratio [aOR] = 2.9, 95% confidence interval [CI]: 1.4–6.3, P = 0.01). Maternal hepatitis B e-antigen (HBeAg) positivity was associated with higher MTCT rate (aOR = 79.1, 95% CI: 10.8–580.2, P
Databáze: OpenAIRE
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