A new immunomodulator, LF 1695 — I. in vitro effects on the T lymphocyte lineage in man
| Autor: | K. Sanhadji, O. Othmane, M. Pascal, Jean-Louis Touraine |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte medicine.medical_specialty T-Lymphocytes Lymphocyte T cell Immunology Bone Marrow Cells Lymphocyte proliferation Lymphocyte Activation T-Lymphocytes Regulatory Adjuvants Immunologic Piperidines Antigen Internal medicine medicine Humans Pharmacology biology Stem Cells Pokeweed mitogen Cell Differentiation T lymphocyte Thymocyte Phenotype medicine.anatomical_structure Endocrinology Concanavalin A Antigens Surface biology.protein |
| Zdroj: | International Journal of Immunopharmacology. 7:543-548 |
| ISSN: | 0192-0561 |
| DOI: | 10.1016/0192-0561(85)90074-8 |
| Popis: | A new immunomodulator, LF 1695, was analyzed in vitro for its capacity to induce T cell markers (HTLA and OKT3, 4 and 8 antigens), to enhance the mitogen-induced lymphocyte proliferation, and to increase the Con A-induced suppressor activity. The inductive activity was compared with that of thymic hormone (thymosin fraction V). LF 1695 was capable of significantly augmenting the percentages of HTLA+ cells (10 – 15 %) and of OKT 3+,T4+, or T8+ cells (13 – 28 %) in human bone marrow prothymocytes. Maximum induction was observed at the concentration of 0.5 μg/ml. In addition, LF 1695 significantly augmented the proliferation of human peripheral blood lymphocytes stimulated by mitogens (Concanavalin A, phytohemagglutinin, pokeweed mitogen and phorbol myristate acetate). LF 1695 also increased the Con A-induced suppressor activity of human lymphocytes. These data indicate that LF 1695 is active both on T cell precursors and on more mature T cells. |
| Databáze: | OpenAIRE |
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