AIDS prevention and control in the Yunnan region by T cell subset assessment
| Autor: | He Zengpin, Ya Li, Yong Duan, Zhong Min, Ruiyang Liu, Ruixuan Fan, Dajin Liu, He Chenglu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male China Lymphocyte CD3 T cell Science Population HIV Infections 010502 geochemistry & geophysics 01 natural sciences Virus 03 medical and health sciences 0302 clinical medicine Acquired immunodeficiency syndrome (AIDS) Risk Factors T-Lymphocyte Subsets Genotype Ethnicity Medicine Humans 030212 general & internal medicine Lymphocyte Count education 0105 earth and related environmental sciences Retrospective Studies education.field_of_study Acquired Immunodeficiency Syndrome Multidisciplinary biology business.industry virus diseases Middle Aged medicine.disease CD4 Lymphocyte Count medicine.anatomical_structure Immunology biology.protein HIV-1 Female business CD8 |
| Zdroj: | PLoS ONE, Vol 14, Iss 4, p e0214800 (2019) |
| ISSN: | 1932-6203 |
| Popis: | BackgroundPrior to being spread throughout broader China, multiple human immunodeficiency virus (HIV)-1 genotypes were originally discovered in the Yunnan Province. As the HIV-1 epidemic continues its spread in Yunnan, knowledge of the influence of gender, age, and ethnicity to instances of HIV reservoirs will benefit monitoring the spread of HIV.MethodsThe degree to which T cells are depleted during an HIV infection depends on the levels of immune activation. T-cell subsets were assessed in newly-diagnosed HIV/AIDS patients in Yunnan, and the influence of age, gender, and ethnicity were investigated. Patients that were newly diagnosed with the HIV-infection between the years 2015 and 2018 at the First Affiliated Hospital of Kunming Medical College were selected for this study (N = 408). The lymphocyte levels and T cell subsets were retrospectively measured in whole blood samples by FACS analysis.ResultsThe median CD4 count was 224 ± 191 cells/μl. Significantly higher mean frequencies and absolute numbers were observed in CD3+, CD3+CD4+, CD3+CD8+, CD45+, and CD3+CD4+/CD45+ in females compared to males. Han patients showed a higher total number of CD3+T cells and the ratio of CD3+ /CD45+ cells compared to any other ethnic minority (P < 0.001). The numbers of CD3+ T-cells, CD3+CD8+ T cells, and CD45+ T cells were highest in the age group ≥ 60. Significant differences were observed in the counts of CD3+, CD3+CD8+, and CD45+ cells and the ratio of CD3+/CD45+ and CD3+CD4+/CD45+ cells between the ≤ 29 and 30-59 age groups.ConclusionThis study has revealed that low levels of CD4+ T cells can be observed in newly-diagnosed HIV/AIDS patients in the Yunnan province. It has also been demonstrated that gender, age, and ethnicity have a significant association with the ratio of T-cell subsets that may contribute to virus progression and disease prognosis in individuals belonging to certain subsets of the population. This study has highlighted the importance of HIV/AIDS screening in at-risk populations to ensure timely and adequate clinical management in Yunnan. |
| Databáze: | OpenAIRE |
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