The effects of melatonin on liver functions in arsenic-induced liver damage
| Autor: | Tuba Gokkus, Filiz Turan, Bulent Bilir, Murat Aydin, İlhan Bali, Ahsen Yilmaz, Seyfi Emir |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Target medicine.medical_specialty Mouse chemistry.chemical_element Aspartate transaminase Environmental pollution melatonin Injury medicine.disease_cause Stress Arsenic Melatonin 03 medical and health sciences Mice Migration-Inhibitory Factor Internal medicine medicine Serum-Levels Original Investigation Inflammation Arsenic toxicity biology Chemistry interleukin-6 Prevention 030104 developmental biology Endocrinology Alanine transaminase biology.protein macrophage migration inhibitory factor Surgery Macrophage migration inhibitory factor monocyte chemotactic protein 1 Oxidative stress medicine.drug Model |
| Popis: | Objective: Arsenic exposure is increasing in communities due to environmental pollution and industrial development. Arsenic is toxic to organ systems because it causes oxidative stress, enzymatic inhibition, and damage to protein structures. The liver, for example, is an organ that may be damaged by arsenic, and this damage may cause various clinical conditions like hepatic failure or cancer. Melatonin is a hormone that acts like an antioxidant, an anti-inflammatory agent, and a cytoprotective agent. In this study, we aimed to evaluate melatonin's protective effects on livers damaged by arsenic toxicity. Materials and Methods: Twenty-four Sprague-Dawley male rats were classified into three groups: a control group, an arsenic applied group, and an arsenic plus 10 mg/kg melatonin applied group. At the end of the fifteen-day experiment, the rats were sacrificed. Albumin, interleukin-6 (IL-6), total protein, alanine transaminase, aspartate transaminase, macrophage migration inhibitory factor, and monocyte chemotactic protein-1 measurements were obtained. Results: In rats with liver damage due to arsenic exposure, melatonin administration significantly decreased the levels of IL-6, macrophage migration inhibitory factor, and monocyte chemotactic protein-1 (p |
| Databáze: | OpenAIRE |
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