Effects of topical application of 1% sodium alendronate gel in the surgical treatment of periodontal intrabony defects: A 6-month randomized controlled clinical trial
| Autor: | Alcione Maria Soares Dutra Oliveira, Fernando Oliveira Costa, Peterson Antônio Dutra Oliveira, Juliana Oliveira Silveira, Bernardo Carvalho Dutra, Luís Otávio Miranda Cota |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Periodontal examination Bleeding on probing Alveolar Bone Loss Dentistry Bone healing Placebo Bone resorption 03 medical and health sciences 0302 clinical medicine Periodontal Attachment Loss medicine Humans Bone regeneration Periodontitis Alendronate business.industry Sodium 030206 dentistry Radiography Dental Digital medicine.disease Clinical trial 030104 developmental biology Treatment Outcome Guided Tissue Regeneration Periodontal Periodontics medicine.symptom Periodontal Index business Follow-Up Studies |
| Zdroj: | Journal of periodontologyREFERENCES. 90(10) |
| ISSN: | 1943-3670 |
| Popis: | BACKGROUND Sodium alendronate (ALN) is an aminobisphosphonate and potent inhibitor of bone resorption. It has been suggested that ALN might be a promising carrier of biomolecules for periodontal bone repair. The aim of this randomized split-mouth clinical trial was to evaluate the effects of the topical application of 1% ALN gel in intrabony defects during the surgical treatment of patients with periodontitis. METHODS Sixty-four intrabony defects from 32 patients with periodontitis were randomly treated with either 1% ALN gel or placebo gel during periodontal surgeries. Full-mouth periodontal examination was performed at baseline and at 3 and 6 months after surgical treatment. Clinical attachment level (CAL), probing depth (PD), and bleeding on probing (BOP) were recorded as the clinical outcomes. Bone defects were evaluated by digital subtraction radiography (DSR) at baseline and 6 months post-treatment. Analyses were performed through Fisher, Kruskal-Wallis, and ANOVA tests and a generalized estimation equations method. RESULTS Both ALN and placebo groups showed significant improvements in BOP, PD, and CAL after periodontal surgical procedures (P |
| Databáze: | OpenAIRE |
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