zPeriaqueductal Grey/Dorsal Raphe Dopamine Neurons Contribute to Sex Differences in Pain-Related Behaviors
| Autor: | Dipanwita Pati, Avery C. Hunker, Karl T. Schmidt, Kristen M. Boyt, Zoe A. McElligott, Larry S. Zweifel, Thomas L. Kash, Waylin Yu, Melanie M. Pina |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Dorsal Raphe Nucleus Male Male mice Pain Mice Transgenic Biology Motor Activity Periaqueductal gray DRDA Article 03 medical and health sciences Mice 0302 clinical medicine Dorsal raphe nucleus Dopamine medicine Animals Periaqueductal Gray Pain Measurement Sex Characteristics Behavior Animal General Neuroscience Dopaminergic Neurons Excitatory Postsynaptic Potentials Stria terminalis 030104 developmental biology medicine.anatomical_structure Nociception Female Nucleus Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Neuron |
| Popis: | Sex differences in pain severity, response, and pathological susceptibility are widely reported, but the neural mechanisms that contribute to these outcomes remain poorly understood. Here we show that dopamine (DA) neurons in the ventrolateral periaqueductal gray/dorsal raphe (vlPAG/DR) differentially regulate pain-related behaviors in male and female mice through projections to the bed nucleus of the stria terminalis (BNST). We find that activation of vlPAG/DRDA+ neurons or vlPAG/DRDA+ terminals in the BNST reduces nociceptive sensitivity during naive and inflammatory pain states in male mice, whereas activation of this pathway in female mice leads to increased locomotion in the presence of salient stimuli. We additionally use slice physiology and genetic editing approaches to demonstrate that vlPAG/DRDA+ projections to the BNST drive sex-specific responses to pain through DA signaling, providing evidence of a novel ascending circuit for pain relief in males and contextual locomotor response in females. |
| Databáze: | OpenAIRE |
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