Can antigliadin antibody detect symptomless coeliac disease in children with short stature?
| Autor: | Umberto Volta, Piero Pirazzoli, Guido Biasco, S Partesotti, Emilio Pisi, F.B. Bianchi, R. Lazzari, M. Feliciani, Paola Tassoni, Emanuele Cacciari, Alessandro Cicognani, Gino Roberto Corazza, Silvana Salardi, Daniela Azzaroni |
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| Rok vydání: | 1985 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Adolescent Duodenum Biopsy Hypopituitarism Immunofluorescence Short stature Gastroenterology Coeliac disease Antibodies Gliadin Growth hormone deficiency Somatomedins Internal medicine Age Determination by Skeleton medicine Humans Villous atrophy Insulin-Like Growth Factor I Child Growth Disorders Plant Proteins medicine.diagnostic_test business.industry General Medicine medicine.disease Body Height Celiac Disease Reticulin El Niño Child Preschool Immunoglobulin G Female medicine.symptom business |
| Zdroj: | Lancet (London, England). 1(8444) |
| ISSN: | 0140-6736 |
| Popis: | Duodenal biopsy and tests for antigliadin antibodies were done in 108 children with short stature unassociated with gastrointestinal symptoms. Other investigations for causes of growth failure were also carried out. In 88 patients, the cause of short stature could not be determined (group I). In 9 patients (8.3%) biopsy showed total villous atrophy, indicating probable coeliac disease (group II), while 7 patients had mild partial villous atrophy (group III). 4 patients (3.7%) had complete growth hormone deficiency. Antigliadin antibodies detected by immunofluorescence (IFL-AGA) were positive in 8 of the 9 group II patients. Symptomless coeliac disease is therefore a commoner cause of short stature than is hypopituitarism; by use of the IFL-AGA test it is possible to select patients for biopsy, thereby identifying most of the coeliac patients. If duodenal biopsies had been limited to IFL-AGA positive patients, 18 biopsies would have been carried out and coeliac disease would have been diagnosed in 8 of the 9 patients. |
| Databáze: | OpenAIRE |
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