Association between the 2-bp deletion polymorphism in the duplicated version of the alpha7 nicotinic receptor gene and P50 sensory gating
| Autor: | Robin M. Murray, Marco Picchioni, Elvira Bramon, Katja Schulze, Eugenia Kravariti, Mei-Hua Hall, Andrew Makoff, Fruhling Rijsdijk, Philip Asherson, Muriel Walshe, Rachel H Flomen, Timothea Toulopoulou, Madiha Shaikh |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Psychosis Adolescent alpha7 Nicotinic Acetylcholine Receptor Biology Receptors Nicotinic Population stratification White People Article Young Adult Gene Frequency Gene Duplication Genetics medicine Diseases in Twins Humans Copy-number variation Allele Allele frequency Genetics (clinical) Genetic association Aged Aged 80 and over Chromosomes Human Pair 15 Sensory gating Polymorphism Genetic Electroencephalography Transmission disequilibrium test Middle Aged Sensory Gating medicine.disease medicine.anatomical_structure Psychotic Disorders Case-Control Studies Female Chromosome Deletion |
| Popis: | There is considerable evidence implicating the 15q13.3 region in neuropsychiatric disorders, with the α7 nicotinic receptor gene CHRNA7 the most plausible candidate. This region has multiple duplications and many copy number variants (CNVs). A common CNV involves a partial duplication of CHRNA7 (CHRFAM7A), which occurs in either orientation. We examined the distribution of these alternative genomic arrangements in a large cohort of psychiatric patients, their relatives and controls using the 2-bp deletion polymorphism as a marker for the orientation of CHRFAM7A. We investigated three common alleles for association with psychosis and with the P50 sensory gating deficit, which is strongly associated with psychosis and strongly linked to 15q13.3. We found significant within-family association with P50 (empirical P=0.004), which is robust to population stratification. Most of the effect came from the 2-bp deletion allele, which tags the variant of CHRFAM7A in the same orientation as CHRNA7. This allele is associated with the presence of the P50 sensory gating deficit (empirical P=0.0006). Tests comparing within-family and between-family components of association suggest considerable population stratification in the sample. We found no evidence for association with psychosis, but this may reflect lower power using this phenotype. Four out of six previous association studies found association of different psychiatric phenotypes with the same 2-bp deletion allele.European Journal of Human Genetics advance online publication, 16 May 2012; doi:10.1038/ejhg.2012.81. link_to_OA_fulltext |
| Databáze: | OpenAIRE |
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