Compartmentalized Response of IL-6/STAT3 Signaling in the Colonic Mucosa Mediates Colitis Development
| Autor: | Carolina Serrano, Alfredo E. Montes-Gómez, Michael Schnoor, Aurora Candelario-Martínez, Sandra Chánez-Paredes, Samuel Galán, Vianney Ortiz-Navarrete, Leticia Cedillo-Barrón, Marco Antonio Meraz-Ríos, Nicolás Villegas-Sepúlveda, José F. Rubio, Porfirio Nava |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
STAT3 Transcription Factor
Colon Immunology Inflammation Stimulation 03 medical and health sciences Interferon-gamma Mice 0302 clinical medicine medicine Immunology and Allergy Animals Humans Secretion Colitis Intestinal Mucosa Autocrine signalling STAT3 Cells Cultured biology Chemistry Interleukin-6 Epithelial Cells medicine.disease digestive system diseases Epithelium Cell biology Mice Inbred C57BL Colonic mucosa medicine.anatomical_structure biology.protein medicine.symptom Caco-2 Cells 030215 immunology Signal Transduction |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950). 202(4) |
| ISSN: | 1550-6606 |
| Popis: | A single layer of polarized epithelial cells lining the colonic mucosa create a semipermeable barrier indispensable for gut homeostasis. The role of intestinal epithelial cell (IEC) polarization in the maintenance of the epithelial homeostasis and in the development of inflammatory bowel diseases is not fully understood. In this review, now we report that IEC polarization plays an essential role in the regulation of IL-6/STAT3 signaling in the colonic mucosa. Our results demonstrate that autocrine STAT3 activation in IECs is mediated by the apical secretion of IL-6 in response to the basolateral stimulation with IFN-γ. This process relies on the presence of functional, IFN-γ−producing CD4+ T cells. In the absence of basolateral IFN-γ, the compartmentalization of the IL-6/STAT3 signaling is disrupted, and STAT3 is activated mainly in macrophages. Thus, in this study, we show that during inflammation, IFN-γ regulates IL-6/STAT3 signaling in IEC in the colonic mucosa. |
| Databáze: | OpenAIRE |
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