| Autor: |
Zofia Klimova, Linh Truong, Martina Fejtkova, Venetia Bigley, Dusana Moravcikova, Catherine F Hatton, Dipayan Mitra, Angela Grainger, Florian Gothe, Veronika Kanderova, Sophie Hambleton, Ales Janda, Joanna E. Perthen, Christopher J A Duncan, Eva Fronkova |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America |
| ISSN: |
1537-6591
1058-4838 |
| Popis: |
We present a case of complete deficiency of the interferon alpha/beta receptor alpha chain (IFNAR1) in a child with fatal systemic hyperinflammation, apparently provoked by live-attenuated viral vaccination. Such pathologic hyperinflammation, fulfilling criteria for hemophagocytic lymphohistiocytosis, is an emerging phenotype accompanying inborn errors of type I interferon immunity. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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