Median Nerve Trauma in a Rat Model of Work-Related Musculoskeletal Disorder
| Autor: | Ann E. Barr, Lisa Beitman, Mary F. Barbe, John P. Gaughan, Talal A. Alshatti, Mamta Amin, Brian D. Clark, Fayez F. Safadi |
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| Rok vydání: | 2003 |
| Předmět: |
Pathology
medicine.medical_specialty Cumulative Trauma Disorders business.industry Connective tissue medicine.disease Work related Article Nerve conduction velocity Pathophysiology Median nerve Median Nerve Rats Rats Sprague-Dawley Disease Models Animal medicine.anatomical_structure Fibrosis Animals Medicine Female Carpal tunnel Musculoskeletal Diseases Neurology (clinical) business Carpal tunnel syndrome |
| Zdroj: | Journal of Neurotrauma. 20:681-695 |
| ISSN: | 1557-9042 0897-7151 |
| DOI: | 10.1089/089771503322144590 |
| Popis: | Anatomical and physiological changes were evaluated in the median nerves of rats trained to perform repetitive reaching. Motor degradation was evident after 4 weeks. ED1-immunoreactive macrophages were seen in the transcarpal region of the median nerve of both forelimbs by 5-6 weeks. Fibrosis, characterized by increased immunoexpression of collagen type I by 8 weeks and connective tissue growth factor by 12 weeks, was evident. The conduction velocity (NCV) within the carpal tunnel showed a modest but significant decline after 9-12 weeks. The lowest NCV values were found in animals that refused to participate in the task for the full time available. Thus, both anatomical and physiological signs of progressive tissue damage were present in this model. These results, together with other recent findings indicate that work-related carpal tunnel syndrome develops through mechanisms that include injury, inflammation, fibrosis and subsequent nerve compression. |
| Databáze: | OpenAIRE |
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