Tibial subchondral trabecular bone micromechanical and microarchitectural properties are affected by alignment and osteoarthritis stage
| Autor: | Sébastien Parratte, Jean-Noël Argenson, Patrick Chabrand, Matthieu Ollivier, Jean-Baptiste Renault, Maximiliano Carmona, Chris Tzioupis |
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| Přispěvatelé: | Institut des Sciences du Mouvement Etienne Jules Marey (ISM), Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2019 |
| Předmět: |
Male
[SDV]Life Sciences [q-bio] lcsh:Medicine Osteoarthritis Condyle Article 03 medical and health sciences Bone volume fraction 0302 clinical medicine Trabecula Medicine Humans Tissue engineering Stage (cooking) lcsh:Science Bone Elastic modulus Aged Mechanical Phenomena 030203 arthritis & rheumatology 030222 orthopedics Multidisciplinary biology Tibia business.industry lcsh:R X-Ray Microtomography Osteoarthritis Knee medicine.disease biology.organism_classification musculoskeletal system Elasticity Biomechanical Phenomena Valgus Trabecular bone medicine.anatomical_structure Cancellous Bone lcsh:Q Female business Nuclear medicine |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) Scientific Reports, Nature Publishing Group, 2020, 10 (1), ⟨10.1038/s41598-020-60464-x⟩ Scientific Reports, 2020, 10 (1), ⟨10.1038/s41598-020-60464-x⟩ |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-60464-x⟩ |
| Popis: | At advanced knee osteoarthritis (OA) stages subchondral trabecular bone (STB) is altered. Lower limb alignment plays a role in OA progression and modify the macroscopic loading of the medial and lateral condyles of the tibial plateau. How the properties of the STB relate to alignment and OA stage is not well defined. OA stage (KL scores 2–4) and alignment (HKA from 17° Varus to 8° Valgus) of 30 patients were measured and their tibial plateau were collected after total knee arthroplasty. STB tissue elastic modulus, bone volume fraction (BV/TV) and trabecula thickness (Tb.Th) were evaluated with nanoindentation and µCT scans (8.1 µm voxel-size) of medial and lateral samples of each plateau. HKA and KL scores were statistically significantly associated with STB elastic modulus, BV/TV and Tb.Th. Medial to lateral BV/TV ratio correlated with HKA angle (R = −0.53, p = 0.016), revealing a higher ratio for varus than valgus subjects. STB properties showed lower values for KL stage 4 patients. Tissue elastic modulus ratios and BV.TV ratios were strongly correlated (R = 0.81, p |
| Databáze: | OpenAIRE |
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