Prolonged QT interval in SARS-CoV-2 infection: prevalence and prognosis
| Autor: | Ermengol Vallès, Camino Fernández, Marc Llagostera, Núria Farré, Diana Mojón, Yolanda Bartolomé, Laia Carla Belarte-Tornero, Alicia Calvo-Fernández, Beatriz Vaquerizo, Ana B García-Duran, Jaume Marrugat, Marcos García-Guimaraes, Alejandro Negrete |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
QT interval
medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lcsh:Medicine 030204 cardiovascular system & hematology Azithromycin Ventricular tachycardia Article 03 medical and health sciences 0302 clinical medicine Internal medicine medicine 030212 general & internal medicine cardiovascular diseases business.industry lcsh:R COVID-19 Hydroxychloroquine General Medicine medicine.disease Prognosis Death Cohort Ventricular fibrillation Cardiology cardiovascular system business medicine.drug |
| Zdroj: | Journal of Clinical Medicine Journal of Clinical Medicine, Vol 9, Iss 2712, p 2712 (2020) Volume 9 Issue 9 |
| Popis: | Background: The prognostic value of a prolonged QT interval in SARS-Cov2 infection is not well known. Objective: To determine whether the presence of a prolonged QT on admission is an independent factor for mortality in SARS-Cov2 hospitalized patients. Methods: Single-center cohort of 623 consecutive patients with positive polymerase-chain-reaction test (PCR) to SARS Cov2, recruited from 27 February to 7 April 2020. An electrocardiogram was taken on these patients within the first 48 h after diagnosis and before the administration of any medication with a known effect on QT interval. A prolonged QT interval was defined as a corrected QT (QTc) interval > 480 milliseconds. Patients were followed up with until 10 May 2020. Results: Sixty-one patients (9.8%) had prolonged QTc and only 3.2% had a baseline QTc > 500 milliseconds. Patients with prolonged QTc were older, had more comorbidities, and higher levels of immune-inflammatory markers. There were no episodes of ventricular tachycardia or ventricular fibrillation during hospitalization. All-cause death was higher in patients with prolonged QTc (41.0% vs. 8.7%, p < 0.001, multivariable HR 2.68 (1.58&ndash 4.55), p < 0.001). Conclusions: Almost 10% of patients with COVID-19 infection have a prolonged QTc interval on admission. A prolonged QTc was independently associated with a higher mortality even after adjustment for age, comorbidities, and treatment with hydroxychloroquine and azithromycin. An electrocardiogram should be included on admission to identify high-risk SARS-CoV-2 patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|