Cross-Cutting Symptom Domains Predict Functioning in Psychotic Disorders

Autor: R. Michael Bagby, Tony P. George, Julia Longenecker, Kwame McKenzie, Lena C. Quilty, Peter Voore, Bruce G. Pollock
Rok vydání: 2021
Předmět:
Zdroj: The Journal of clinical psychiatry. 82(2)
ISSN: 1555-2101
Popis: OBJECTIVE Previous research shows elevated disability in psychotic disorders. However, co-occurring symptomatology has been increasingly highlighted as predictive of clinical outcomes in the psychotic spectrum. The current study investigates how both psychotic and nonpsychotic symptom domains predict functioning across psychotic disorders. METHODS Outpatients (N = 128) with psychotic spectrum diagnoses participated in the Diagnostic and Statistical Manual for Mental Disorders, Fifth Edition (DSM-5) Field Trials at the Centre for Addiction and Mental Health in Toronto, Canada, in 2011, including the repeated administration of "cross-cutting" brief screening measures that assessed internalizing (eg, anxiety, depression), substance use (eg, alcohol, psychoactive drug use), and psychotic symptoms. Level of functioning was also assessed by self-report and clinician-rated World Health Organization Disability Assessment Schedule 2.0 (WHO-DAS-II). The relation between symptom domains and disability was examined concurrently and prospectively via hierarchical regression. RESULTS Psychosis was strongly linked to self-reported disability when considered in isolation (β = 0.22, P
Databáze: OpenAIRE