Soft subdermal implant capable of wireless battery charging and programmable controls for applications in optogenetics
| Autor: | Min Jeong Ku, Jae Hyung Jang, Raza Qazi, Shane Oh, Jeong-Hoon Kim, Choong Yeon Kim, Inho Kang, Jae-Woong Jeong, Wha Young Kim, Jong Woo Park, Kum Seok Nam, Hong Jae Nam |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Battery (electricity)
Male Computer science Deep Brain Stimulation Science General Physics and Astronomy Optogenetics General Biochemistry Genetics and Molecular Biology Subdermal implant Article Rats Sprague-Dawley Wireless Animals Humans Wireless power transfer Multidisciplinary business.industry Brain General Chemistry Electrical and electronic engineering Electrodes Implanted Sprague dawley Neuroscience research business Electromagnetic Phenomena Wireless Technology Biomedical engineering Computer hardware Locomotion |
| Zdroj: | Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021) Nature Communications |
| ISSN: | 2041-1723 |
| Popis: | Optogenetics is a powerful technique that allows target-specific spatiotemporal manipulation of neuronal activity for dissection of neural circuits and therapeutic interventions. Recent advances in wireless optogenetics technologies have enabled investigation of brain circuits in more natural conditions by releasing animals from tethered optical fibers. However, current wireless implants, which are largely based on battery-powered or battery-free designs, still limit the full potential of in vivo optogenetics in freely moving animals by requiring intermittent battery replacement or a special, bulky wireless power transfer system for continuous device operation, respectively. To address these limitations, here we present a wirelessly rechargeable, fully implantable, soft optoelectronic system that can be remotely and selectively controlled using a smartphone. Combining advantageous features of both battery-powered and battery-free designs, this device system enables seamless full implantation into animals, reliable ubiquitous operation, and intervention-free wireless charging, all of which are desired for chronic in vivo optogenetics. Successful demonstration of the unique capabilities of this device in freely behaving rats forecasts its broad and practical utilities in various neuroscience research and clinical applications. Although wireless optogenetic technologies enable brain circuit investigation in freely moving animals, existing devices have limited their full potential, requiring special power setups. Here, the authors report fully implantable optogenetic systems that allow intervention-free wireless charging and controls for operation in any environment. |
| Databáze: | OpenAIRE |
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