Characterisation of the absorption, distribution, metabolism, excretion and mass balance of doravirine, a non-nucleoside reverse transcriptase inhibitor in humans

Autor:	Martin O. Behm, Rosa I. Sanchez, Bing Lu, Kerry L. Fillgrove, Rachael Liu, Matt S. Anderson, Ka Lai Yee, Marian Iwamoto, Yun Li, Sauzanne Khalilieh, Li Fan, Joan R. Butterton, Yuexia Liang, Aditya Tatavarti
Rok vydání:	2018
Předmět:	Adult Male Pyridones Health Toxicology and Mutagenesis Human immunodeficiency virus (HIV) Absorption (skin) Toxicology medicine.disease_cause 030226 pharmacology & pharmacy Biochemistry Nucleoside Reverse Transcriptase Inhibitor Excretion 03 medical and health sciences chemistry.chemical_compound Young Adult 0302 clinical medicine Doravirine medicine Distribution (pharmacology) Humans Tissue Distribution ATP Binding Cassette Transporter Subfamily B Member 1 Pharmacology Reverse-transcriptase inhibitor Chemistry General Medicine Metabolism Middle Aged Triazoles Absorption Physiological 030220 oncology & carcinogenesis Metabolome Reverse Transcriptase Inhibitors Administration Intravenous medicine.drug
Zdroj:	Xenobiotica; the fate of foreign compounds in biological systems. 49(4)
ISSN:	1366-5928
Popis:	Absorption, distribution, metabolism and elimination of doravirine (MK-1439), a novel non-nucleoside reverse transcriptase inhibitor, were investigated. Two clinical trials were conducted in healthy subjects: an oral single dose [
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ebba60e59fa4b740fffc760e5c55c4d https://pubmed.ncbi.nlm.nih.gov/29557716 Zobrazit plný text záznamu