Effects of acetazolamide on kidney function in type 1 (insulin-dependent) diabetic patients with diabetic nephropathy
| Autor: | H. H. Parving, Eva Hommel, Peter Skøtt, N. E. Bruun, S. Arnold-Larsen |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Renal function Blood Pressure Kidney Kidney Function Tests Nephropathy Diabetic nephropathy Reference Values Internal medicine Diabetes mellitus Internal Medicine medicine Albuminuria Humans Diabetic Nephropathies Reabsorption business.industry medicine.disease Acetazolamide Endocrinology medicine.anatomical_structure Diabetes Mellitus Type 1 Renal physiology Diuretic business Glomerular Filtration Rate |
| Zdroj: | Diabetologia. 31(11) |
| ISSN: | 0012-186X |
| Popis: | We investigated the effects of 3 days treatment with acetazolamide 250 mg three times daily on kidney function in 8 Type 1 (insulin-dependent) diabetic patients with nephropathy, and in 7 healthy subjects in a double-blind placebo controlled cross-over study. Glomerular filtration rate and extracellular fluid volume were measured with the single injection 51Cr-EDTA technique and fluid flow rate from the proximal tubules was determined by measurement of the renal lithium clearance. A 24% decline in glomerular filtration rate was observed in both groups during acetazolamide treatment (control subjects: 108 +/- 11 vs 82 +/- 9 ml/min, p less than 0.02, diabetic patients: 71 +/- 19 vs 54 +/- 14 ml/min, p less than 0.01). The renal lithium clearance (ml/min) remained about the same (control subjects: 22 +/- 6 vs 27 +/- 8, NS, diabetic patients: 14 +/- 5 vs 15 +/- 4, NS). Absolute proximal tubular reabsorption of water (ml/min) was reduced by about one-third (control subjects: 85 +/- 11 vs 56 +/- 7, p less than 0.02, diabetic patients: 55 +/- 17 vs 37 +/- 6, p less than 0.02), and fractional proximal reabsorption of water and sodium (%) declined (control subjects: 79 +/- 5 vs 67 +/- 8, p less than 0.02, diabetic patients: 79 +/- 5 vs 72 +/- 6, p less than 0.02). Renal sodium clearance and distal fractional reabsorption of sodium was unchanged. Extracellular fluid volume declined by 10% in both groups (p less than 0.02). Albuminuria and fractional albumin clearance decreased significantly in the nephropathic patients (p less than 0.02).(ABSTRACT TRUNCATED AT 250 WORDS) |
| Databáze: | OpenAIRE |
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