Sensitivity of camptothecin-resistant human leukemia cells and tumors to anticancer drugs with diverse mechanisms of action
| Autor: | Dana Vardeman, Albert DeJesus, Janet Early, John Mendoza, A. J. Kozielski, Panayotis Pantazis, Beppino C. Giovanella |
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| Rok vydání: | 1995 |
| Předmět: |
Male
Cancer Research Vincristine Nitrosourea Daunorubicin Drug Resistance Mice Nude Antineoplastic Agents Apoptosis Biology Mice chemistry.chemical_compound medicine Animals Humans Topoisomerase II Inhibitors Amsacrine Etoposide Leukemia Cell Cycle DNA Neoplasm Hematology Flow Cytometry medicine.disease Mitotic inhibitor Oncology chemistry Immunology Cancer research Camptothecin Drug Screening Assays Antitumor Cell Division medicine.drug |
| Zdroj: | Leukemia Research. 19:43-55 |
| ISSN: | 0145-2126 |
| DOI: | 10.1016/0145-2126(94)00060-n |
| Popis: | Human leukemia U-937 cell clones resistant to 9-nitrocamptothecin (9NC) appear after exposure to increase 9NC-concentrations. Drug resistance is irreversible, regardless of whether the 9NC-resistant (U-937/CR150) cells grow in media with or without 9NC. U-937/ CR150 cells are more sensitive than wild type U-937 (U-937/wt) cells to topoisomerase II-directed drugs, amsacrine, daunorubicin, and etoposide. The mitotic inhibitor, vincristine, induces hyperdiploidy in U-937/wt, but not in U-937/CR150 cells, whereas the antimetabolites, cytarabine and methotrexate, and the nitrosourea, carmustine, elicit similar responses in both U-937/wt and U-937/CR150 cells. U-937/CR150-generated tumors in nude mice are sensitive to etoposide. The clinical implications of increased sensitivity of 9NC-resistant tumors to some anticancer drugs are discussed. |
| Databáze: | OpenAIRE |
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