Exercise training improves cardiopulmonary and endothelial function in women with breast cancer: findings from the Diana-5 dietary intervention study
| Autor: | Luigi Maresca, Franco Berrino, Francesco Giallauria, Maria Elisabetta Mancini, Alessandra Grieco, Carlo Vigorito, Paolo Chiodini, Amalia Mattiello, Giorgio Torella, Marco Gentile, Angelo Russo, Alessandra Vitelli, Maria Santucci de Magistris, Rosa Lucci, Salvatore Panico |
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| Přispěvatelé: | Giallauria, Francesco, Vitelli, Alessandra, Maresca, Luigi, Santucci de Magistris, Maria, Chiodini, Paolo, Mattiello, Amalia, Gentile, Marco, Mancini, Maria, Grieco, Alessandra, Russo, Angelo, Lucci, Rosa, Torella, Giorgio, Berrino, Franco, Panico, Salvatore, Vigorito, Carlo, Santucci De Magistris, Maria |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Adult
medicine.medical_specialty Mediterranean diet Breast Neoplasms 030204 cardiovascular system & hematology Diet Mediterranean Exercise training 03 medical and health sciences Oxygen Consumption 0302 clinical medicine Breast cancer Internal medicine medicine Internal Medicine Humans Reactive hyperemia Aged Cancer business.industry Endothelial function Middle Aged medicine.disease Intervention studies Pathophysiology Exercise Therapy Cardiopulmonary exercise testing 030220 oncology & carcinogenesis Cancer evolution Exercise Test Cardiology Physical therapy Emergency Medicine Female Endothelium Vascular business Metabolic profile |
| Popis: | To investigate whether exercise training (ET) improves cardiopulmonary and endothelial function in women with breast cancer (BC). Fifty-one female patients (aged between 39 and 72 years) with a history of primary invasive BC within the previous 5 years and enrolled in the Mediterranean diet-based DIANA (diet and androgens)-5 Trial were subdivided into 2 groups: an ET group (n = 25) followed a formal ET program of moderate intensity (3 session/week on a bicycle at 60-70 % VO2peak for 3 months, followed by one session/week until 1-year follow-up), while a control group (n = 26) did not perform any formal ET. At baseline and at 1-year follow-up, all patients underwent cardiopulmonary exercise stress test (CPET) and measurements of vascular endothelial function by peripheral artery tonometry (Reactive Hyperemia Index, RHI). There were no significant differences between the groups in baseline anthropometrical, BC characteristics, and metabolic profile. No differences in baseline CPET and RHI parameters were found. Peak oxygen consumption (VO2peak) significantly increased in ET group (from 12.4 ± 2.9 to 14.3 ± 3.3 mL/kg/min, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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