A prospective study on obesity and subcutaneous fat patterning in relation to breast cancer in post-menopausal women participating in the DOM project
| Autor: | I. den Tonkelaar, H. J. A. Collette, F. de Waard, Jacob C. Seidell |
|---|---|
| Přispěvatelé: | Youth and Lifestyle |
| Rok vydání: | 1994 |
| Předmět: |
Cancer Research
medicine.medical_specialty Population Breast Neoplasms Research Support Breast cancer screening Breast cancer SDG 3 - Good Health and Well-being Risk Factors Internal medicine Confidence Intervals Journal Article medicine Humans Obesity Prospective Studies Risk factor Non-U.S. Gov't education Prospective cohort study Aged Netherlands education.field_of_study Anthropometry medicine.diagnostic_test business.industry Obstetrics Research Support Non-U.S. Gov't Incidence Incidence (epidemiology) Middle Aged medicine.disease Postmenopause Endocrinology Adipose Tissue Oncology Female business Research Article Follow-Up Studies |
| Zdroj: | den Tonkelaar, I, Seidell, J C, Collette, H J & de Waard van de Spek, FB 1994, ' A prospective study on obesity and subcutaneous fat patterning in relation to breast cancer in post-menopausal women participating in the DOM project ', British Journal of Cancer, vol. 69, no. 2, pp. 352-7 . https://doi.org/10.1038/bjc.1994.64 British Journal of Cancer British Journal of Cancer, 69(2), 352-7. Nature Publishing Group |
| ISSN: | 1532-1827 0007-0920 |
| DOI: | 10.1038/bjc.1994.64 |
| Popis: | The associations of body fat and body fat distribution with breast cancer risk were examined in a prospective study in 9,746 post-menopausal women with a natural menopause, aged 49-66 at intake, participating in a breast cancer screening project (the DOM project in Utrecht). During a follow-up period of 15 years (mean follow-up time 12.5 years) 260 women developed breast cancer. Fat distribution, assessed by contrasting groups of subcapsular and triceps skinfold thickness, was found to be unrelated to breast cancer incidence. No significant relationship between body fat, measured either by weight, Quetelet's index, triceps skinfold or subscapular skinfold, and breast cancer risk was found when analysed in quartiles. However, women in the upper decile compared with the lower decile of the distribution of Quetelet's index were found to have a 1.9 times (95% CI 1.1-3.3) higher risk for breast cancer. These results seemed to be in contrast with the significant positive association between fatness, analysed in quartiles, and breast cancer observed in a cross-sectional study, based on mammographic screening, carried out previously in the same population. Although the differences between the present, prospective, study and our cross-sectional study may be due to chance it may be that there are differences between characteristics of breast cancer detected at screening and subsequently, which influence the associations between measures of fatness and risk of breast cancer. |
| Databáze: | OpenAIRE |
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