The Role of miRNA for the Treatment of MGMT Unmethylated Glioblastoma Multiforme

Autor: Stephanie E. Combs, Thomas E. Schmid, Anna Kirstein
Rok vydání: 2020
Předmět:
Zdroj: Cancers 12:1099 (2020)
Cancers, Vol 12, Iss 1099, p 1099 (2020)
Cancers
ISSN: 2072-6694
DOI: 10.3390/cancers12051099
Popis: Glioblastoma multiforme (GBM) is the most common high-grade intracranial tumor in adults. It is characterized by uncontrolled proliferation, diffuse infiltration due to high invasive and migratory capacities, as well as intense resistance to chemo- and radiotherapy. With a five-year survival of less than 3% and an average survival rate of 12 months after diagnosis, GBM has become a focus of current research to urgently develop new therapeutic approaches in order to prolong survival of GBM patients. The methylation status of the promoter region of the O6-methylguanine–DNA methyltransferase (MGMT) is nowadays routinely analyzed since a methylated promoter region is beneficial for an effective response to temozolomide-based chemotherapy. Furthermore, several miRNAs were identified regulating MGMT expression, apart from promoter methylation, by degrading MGMT mRNA before protein translation. These miRNAs could be a promising innovative treatment approach to enhance Temozolomide (TMZ) sensitivity in MGMT unmethylated patients and to increase progression-free survival as well as long-term survival. In this review, the relevant miRNAs are systematically reviewed.
Databáze: OpenAIRE
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