Risk Stratification of High-grade Prostate Cancer Treated with Antegrade Radical Prostatectomy with Intended Wide Resection
| Autor: | Shinya Yamamoto, Satoru Kawakami, Junji Yonese, Yuhei Ohkubo, Yuichi Ishikawa, Iwao Fukui, Tetsuro Tsukamoto, Yasuhisa Fujii, Yoshinobu Komai |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty medicine.medical_treatment Urology urologic and male genital diseases Prostate cancer PSA Failure medicine Humans Neoplasm Invasiveness Radiology Nuclear Medicine and imaging Survival rate Survival analysis Aged Neoplasm Staging Prostatectomy business.industry Proportional hazards model Prostatic Neoplasms General Medicine Middle Aged Prostate-Specific Antigen medicine.disease Survival Rate Prostate-specific antigen Treatment Outcome Oncology Evaluation Studies as Topic Multivariate Analysis Cohort business |
| Zdroj: | Japanese Journal of Clinical Oncology. 39:387-393 |
| ISSN: | 1465-3621 0368-2811 |
| DOI: | 10.1093/jjco/hyp032 |
| Popis: | Objective: The aim of this study was to assess the surgical outcome of high-grade prostate cancer (PCA) treated with antegrade radical prostatectomy with intended wide resection (aRP) and to establish the risk stratification. Methods: A consecutive 77 Japanese patients with Gleason score 8‐10 PCA were treated with aRP alone and excluding patients with persistently elevated prostate-specific antigen (PSA), prospectively observed without any treatment until PSA failure was confirmed. PSA failure-free, cancer-specific and overall survival curves were generated with Kaplan‐Meier method and the difference between groups was assessed with log-rank test. Cox’s proportional hazards model was used to elucidate predictors of PSA failure. Results: During a median follow-up of 6 years, PSA failure was observed in 41 (53%) of the 77 patients. Five- and 10-year PSA failure-free survival rates of the entire cohort were 44.6% and 40.1%, respectively. Both overall and cancer-specific survival rates of the entire cohort at 5 and 10 years were 96.8% and 87.9%, respectively. In a multivariate analysis, PSA (P ¼ 0.008), specimen confinement (SC) (P ¼ 0.006) and persistently elevated PSA after aRP were identified as significant and independent predictors of PSA failure. When stratifying patients into three risk groups according to PSA level and SC status, PSA failure-free survival rate in patients with PSA , 10 ng/ml and specimen-confined disease (SCD) was significantly better than that in those of any other groups. Conclusions: Good prognosis can be expected in patients with high-grade PCA treated with aRP alone when PSA , 10 ng/ml and the tumor was removed as an SCD. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|