Differential activity of subgenual cingulate and brainstem in panic disorder and PTSD
| Autor: | Almut Engelien, Hong Pan, Martin Goldstein, Daniella J. Furman, James C. Root, Marylene Cloitre, Yihong Yang, Xenia Protopopescu, Joseph E. LeDoux, Tracy Butler, Jack M. Gorman, David Silbersweig, Michael Gordon Silverman, Emily Stern, Oliver Tuescher |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Cingulate cortex medicine.medical_specialty Conditioning Classical Poison control Audiology Gyrus Cinguli Amygdala Article Stress Disorders Post-Traumatic Image Processing Computer-Assisted medicine Humans Brain Mapping Resting state fMRI Panic disorder Panic Fear Middle Aged medicine.disease Magnetic Resonance Imaging Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Panic Disorder Anxiety Female medicine.symptom Psychology Neuroscience Anxiety disorder Brain Stem |
| Zdroj: | Journal of Anxiety Disorders. 25:251-257 |
| ISSN: | 0887-6185 |
| DOI: | 10.1016/j.janxdis.2010.09.010 |
| Popis: | Most functional neuroimaging studies of panic disorder (PD) have focused on the resting state, and have explored PD in relation to healthy controls rather than in relation to other anxiety disorders. Here, PD patients, Posttraumatic stress disorder (PTSD) patients, and healthy control subjects were studied with functional magnetic resonance imaging utilizing an instructed fear conditioning paradigm incorporating both Threat and Safe conditions. Relative to PTSD and control subjects, PD patients demonstrated significantly less activation to the Threat condition and increased activity to the Safe condition in the subgenual cingulate, ventral striatum and extended amygdala, as well as in midbrain periaquaeductal grey, suggesting abnormal reactivity in this key region for fear expression. PTSD subjects failed to show the temporal pattern of activity decrease found in control subjects. |
| Databáze: | OpenAIRE |
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