Di-(2-propylheptyl) phthalate (DPHP) and its metabolites in blood of rats upon single oral administration of DPHP
| Autor: | Winfried Kessler, Dominik Klein, Johannes G. Filser, Rainer Otter, Brigitte Semder, J. Lichtmannegger, Christian Pütz |
|---|---|
| Jazyk: | němčina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male Glucuronidation Phthalic Acids Administration Oral 010501 environmental sciences Pharmacology Toxicology 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Oral administration Animals Rats Wistar 0105 earth and related environmental sciences Chemistry Di-(2-propylheptyl) Phthalate Blood Metabolites Oral Treatment Rat Phthalate General Medicine Bioavailability Rats 030104 developmental biology Endocrine disruptor DPHP Toxicity Environmental Pollutants Toxicant |
| Zdroj: | Toxicol. Lett. 259, 80-86 (2016) |
| Popis: | Di-(2-propylheptyl) phthalate (DPHP) does not act as a reproductive toxicant or endocrine disruptor in contrast to other phthalates. Considering adverse effects of phthalates to be linked to their metabolism, it was the aim of the present study to investigate in the rat the blood burden of DPHP and its metabolites as a basis for understanding the toxicological behavior of DPHP. Rats were administered single oral doses of DPHP of 0.7 and 100mg/kg body weight. Concentration-time courses of DPHP and metabolites were monitored in blood. The areas under the concentration-time curves in blood (AUCs), normalized for the dose of DPHP, showed the following order: DPHP |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|