Low complication rate associated with cesarean section under spinal anesthesia for HIV-1-infected women on antiretroviral therapy
| Autor: | J Welch, Mark Zuckerman, Anton Pozniak, Theresa Leung, Margaret Blott, Philippa Groves, Edward Davies, Colin Ball, Michael S. Avidan |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
medicine.medical_specialty Blood transfusion Adolescent Anti-HIV Agents medicine.medical_treatment Hemodynamics HIV Infections Anesthesia Spinal Postoperative Complications Acquired immunodeficiency syndrome (AIDS) Pregnancy Medicine Humans business.industry Cesarean Section medicine.disease Surgery Anesthesiology and Pain Medicine Blood pressure Anesthesia Case-Control Studies HIV-1 Female Viral disease business Complication Viral load |
| Zdroj: | Anesthesiology. 97(2) |
| ISSN: | 0003-3022 |
| Popis: | Background Elective cesarean section decreases the likelihood of vertical human immunodeficiency virus (HIV) transmission from mother to infant. This study aimed to determine whether cesarean section done with spinal anesthesia on HIV-1-infected pregnant women taking antiretroviral therapy is associated with intraoperative hemodynamic instability, postoperative complications, or changes in immune function or HIV-1 viral load. Methods A case-controlled study was conducted over a 3-year period in a London academic hospital. Forty-four women infected with HIV-1 and a control group of 45 HIV-negative women undergoing cesarean sections were included. The main outcome measures included intraoperative blood pressure, heart rate, blood loss, and ephedrine requirements, and postoperative infective complications, blood transfusion, changes in blood HIV-1 viral load and lymphocyte subsets, and time to hospital discharge. Results There were no differences in hemodynamic stability and postoperative complications between the HIV-infected group and the controls. There was an acute postoperative increase in the CD4T lymphocyte count (P = 0.01), but the CD4T:CD8T ratio and viral load did not change. Conclusions Elective cesarean section under spinal anesthesia for women infected with HIV-1 taking antiretroviral therapy was not associated with intraoperative or postoperative complications. |
| Databáze: | OpenAIRE |
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