Effect of Statin Therapy Before Q-Wave Myocardial Infarction on Myocardial Perfusion
| Autor: | Philipp Christott, Hasna Suliman, Rüdiger Blindt, Philipp K. Haager, Rainer Hoffmann, Malte Kelm, Peter W. Radke |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Statin medicine.drug_class medicine.medical_treatment Myocardial Infarction Coronary Angiography Systemic inflammation Revascularization Drug Administration Schedule Electrocardiography Heart Conduction System Coronary Circulation Internal medicine Preoperative Care medicine Humans cardiovascular diseases Platelet activation Myocardial infarction Angioplasty Balloon Coronary business.industry Middle Aged medicine.disease C-Reactive Protein Treatment Outcome medicine.anatomical_structure Circulatory system Cardiology Female Hydroxymethylglutaryl-CoA Reductase Inhibitors medicine.symptom Cardiology and Cardiovascular Medicine business Perfusion Artery |
| Zdroj: | The American Journal of Cardiology. 101:139-143 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/j.amjcard.2007.07.059 |
| Popis: | Recent studies emphasized the non-lipid-lowering effects of hydroxymethylglutaryl coenzyme A reductase inhibitors on endothelial function, inflammation, and platelet activation in patients with stable atherosclerosis. This study sought to evaluate the impact of statin pretreatment in patients with acute myocardial infarction (AMI) on level of systemic inflammation and myocardial perfusion. A total of 253 consecutive patients undergoing primary angioplasty on a native vessel within 12 hours of AMI were divided into a group with statin pretreatment (n = 86) and control patients (n = 167). Angiographic myocardial blush grade (MBG) after revascularization of the infarct-related artery was determined to evaluate myocardial perfusion. Statin pretreatment was associated with a lower frequency of increased C-reactive protein (or=5 mg/L) on admission compared with the control group (48% vs 64%; p = 0.019). The frequency of normal perfusion (MBG 3) was higher in the statin-pretreatment group than the control group (45% vs 26%, respectively; p0.001). Statin pretreatment was an independent predictor of normal myocardial perfusion (MBG 3; odds ratio 2.53, 95% confidence interval 1.15 to 9.53, p = 0.022) in addition to ageor=70 years and C-reactive protein5 mg/L. In conclusion, statin pretreatment in patients with AMI was associated with decreased systemic inflammation and better perfusion after primary angioplasty of the infarct-related artery. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect