Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia
| Autor: | Thomas V. Adamkiewicz, B. Sleight, Peter A. Lane, Keith M. Sullivan, A. Haight, Barry Eggleston, Lewis L. Hsu, N. Kamani, John T. Horan, Roger Giller, Rupa Redding-Lallinger, Alexis A. Thompson, T. B. Moore, George R. Buchanan, J. E. Levine, J. E. Sanders, S. Donfield, Sandie Edwards, David A. Margolis, R. Dickerhoff, S. A. Feig, J. P. Scott, Mark C. Walters, S. C. Davies, Zora R. Rogers, Melinda Patience, I. A.G. Roberts, K. Ohene-Frempong |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Hemolytic anemia Oncology Aging medicine.medical_specialty Anemia Anemia Sickle Cell Growth Weight Gain Antisickling Agents hemic and lymphatic diseases Internal medicine medicine Humans Hydroxyurea Child Adverse effect Bone Marrow Transplantation Hematology business.industry Age Factors medicine.disease Body Height Sickle cell anemia Transplantation surgical procedures operative medicine.anatomical_structure Hemoglobinopathy Child Preschool Immunology Female Bone marrow business Follow-Up Studies |
| Zdroj: | British Journal of Haematology. 136:673-676 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/j.1365-2141.2006.06486.x |
| Popis: | Although haematopoietic cell transplantation (HCT) is curative for sickle cell anaemia (SCA), concerns about its short- and long-term toxicities limit its application. A potential toxicity is an adverse effect on growth. To identify an HCT growth effect, serial height and weight measurements from 53 children and adolescents with SCA after receiving a transplant were compared to historical controls. Hierarchical Linear Models for longitudinal data were used for analysis. In general growth was not impaired by HCT for SCA in young children; however, diminished growth may occur if HCT is carried out near or during the adolescent growth spurt. |
| Databáze: | OpenAIRE |
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