Primary clear cell meningioma of the orbit mimicking a metastatic carcinoma: usefulness of immunohistochemistry and cytogenetic analysis

Autor: Guillaume Odin, Elodie Basc, Florence Pedeutour, Elodie Long, Basile Pasquier, Véronique Hofman, Paul Hofman, Maxime Benchetritt
Přispěvatelé: Laboratory of Clinical and Experimental Pathology, Centre Hospitalier Universitaire de Nice (CHU Nice), Department of Otorhinolaryngology, Laboratory of Solid Tumors Genetics, Nice University Hospital, Department of Pathology, Hôpital Michallon, Institut de signalisation, biologie du développement et cancer (ISBDC), Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Human Tissue Biobank Unit, Hôpital Pasteur [Nice] (CHU)
Rok vydání: 2008
Předmět:
Male
MESH: Combined Modality Therapy
MESH: Fatal Outcome
Pathology
Chromosomes
Human
Pair 22
Vimentin
MESH: Meningioma
Metastasis
Fatal Outcome
Monosomy
MESH: Aged
80 and over
0302 clinical medicine
Meningeal Neoplasms
MESH: Orbital Neoplasms
MESH: Chromosomes
Human
Pair 22
Aged
80 and over
biology
General Medicine
Combined Modality Therapy
Immunohistochemistry
MESH: Monosomy
3. Good health
MESH: Spectral Karyotyping
030220 oncology & carcinogenesis
Cytogenetic Analysis
Clear cell carcinoma
Meningioma
medicine.medical_specialty
[SDV.CAN]Life Sciences [q-bio]/Cancer
Adenocarcinoma
Pathology and Forensic Medicine
Metastatic carcinoma
Diagnosis
Differential
03 medical and health sciences
MESH: Diagnosis
Differential
Biomarkers
Tumor
medicine
Carcinoma
Clear Cell Meningioma
Humans
Molecular Biology
MESH: Humans
MESH: Cytogenetic Analysis
Spectral Karyotyping
MESH: Adenocarcinoma
MESH: Immunohistochemistry
Cell Biology
MESH: Meningeal Neoplasms
medicine.disease
MESH: Male
[SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics
MESH: Tumor Markers
Biological
biology.protein
Orbital Neoplasms
030217 neurology & neurosurgery
Clear cell
Zdroj: Archiv für pathologische Anatomie und Physiologie und für klinische Medicin
Archiv für pathologische Anatomie und Physiologie und für klinische Medicin, 2008, 452 (2), pp.209-13. ⟨10.1007/s00428-007-0519-z⟩
ISSN: 1432-2307
0945-6317
DOI: 10.1007/s00428-007-0519-z
Popis: Clear cell meningiomas (CCM) are rare tumors of the nervous system that usually occur in young patients and display high recurrence rates and potentially aggressive behavior. In this report, we describe a primary CCM of the orbit in an 84-year-old man with a previous history of a clear cell carcinoma of the kidney. Histologically, the tumor demonstrated a sheet-like proliferation of clear polygonal cells. Differential diagnosis includes metastasis of clear cell carcinomas. Immunohistochemistry, by showing that tumor cells expressed vimentin, epithelial membrane antigen, and progesterone antigens, and cytogenetic analysis, by identifying a monosomy 22, confirmed the diagnosis of CCM.
Databáze: OpenAIRE
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