Hemostatic complications in young patients with essential thrombocythemia
| Autor: | David S. Rosenthal, Piera Viero, Anna Mitus, Tiziano Barbui, Andrew I. Schafer, Lawrence N. Shulman, Sergio Cortelazzo |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Adolescent Platelet Aggregation Hemorrhage Disease Medical Records medicine Humans Child Retrospective Studies Platelet Count business.industry Essential thrombocythemia Incidence (epidemiology) Medical record Clinical course Thrombosis Retrospective cohort study General Medicine Prognosis medicine.disease Community health Female business Thrombocythemia Essential |
| Zdroj: | The American Journal of Medicine. 88:371-375 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/0002-9343(90)90491-u |
| Popis: | purpose: The purpose of this study was to determine the incidence of hemostastic complications in young patients with essential thrombocythemia (ET). patients and methods: The clinical course of 44 patients under the age of 45 with the diagnosis of ET was reviewed in a retrospective manner. Patients were collected from three medical centers in the United States and Italy: the Brigham and Women's Hospital and the Harvard Community Health Plan, Boston, Massachusetts, and the Ospedali Riuniti di Bergamo, Bergamo, Italy. results: The overall incidence of hemorrhage or thrombosis, or both, in this group of patients was 39% (17 of 44), with serious complications occurring in 23% (10 of 44). Two patients died of thrombotic events. Neither the presence of symptoms at diagnosis nor any single laboratory parameter proved predictive of clinical sequelae. Treatment with antiplatelet drugs or platelet-lowering agents was not protective. conclusion: We conclude that ET in young patients may result in serious and life-threatening hemostatic problems and consequently that young age is not a favorable prognostic factor in this disease. |
| Databáze: | OpenAIRE |
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