Coronary artery calcification and risk of mortality and adverse outcomes in patients with COVID-19: a Chinese multicenter retrospective cohort study
| Autor: | Song Luo, Bing Wan, Yi Yang, Shi Jun Jia, Wei Chen, Chao Du, Yu Ting Yang, Juan Zhu, Jiang Tao Wang, Li Na Zhang, Xiao Li, Fei Xia, Meng Jie Lu, Xiao Ming Qiu, Xian Jun Zeng, Guangming Lu, Li Qi, Zi Yue Zu, Rong Hua Tian, Jing Zhong, Bin Fan, Hao Ren, Ran Yang, Kai Xu, Can Zhang, Jian Bo Gao, Mei Yun Wang, Qi Rui Zhang, Hui Jie Jiang, Long Jiang Zhang, Xiao Xue Liu, Dong You Zhang, Yi Liang, Peng Peng Xu, Yu Xiu Liu, Chang Sheng Zhou, Feng Chen, Xi Ming Wang, Wei Zhang |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Mechanical ventilation
medicine.medical_specialty Polymers and Plastics Coronavirus disease 2019 business.industry Proportional hazards model medicine.medical_treatment Hazard ratio nutritional and metabolic diseases Retrospective cohort study Coronary artery calcification Cardiovascular disease Intensive care unit law.invention law Internal medicine medicine Risk of mortality Original Article cardiovascular diseases Risk factor Mortality business Adverse effect General Environmental Science |
| Zdroj: | Chinese Journal of Academic Radiology |
| ISSN: | 2520-8993 2520-8985 |
| Popis: | Background Coronary artery calcification (CAC) is an independent risk factor of major adverse cardiovascular events; however, the impact of CAC on in-hospital death and adverse clinical outcomes in patients with coronavirus disease 2019 (COVID-19) remains unclear. Objective To explore the association between CAC and in-hospital mortality and adverse events in patients with COVID-19. Methods This multicenter retrospective cohort study enrolled 2067 laboratory-confirmed COVID-19 patients with definitive clinical outcomes (death or discharge) admitted from 22 tertiary hospitals in China between January 3, 2020 and April 2, 2020. Demographic, clinical, laboratory results, chest CT findings, and CAC on admission were collected. The primary outcome was in-hospital death and the secondary outcome was composed of in-hospital death, admission to intensive care unit (ICU), and requiring mechanical ventilation. Multivariable Cox regression analysis and Kaplan–Meier plots were used to explore the association between CAC and in-hospital death and adverse clinical outcomes. Results The mean age was 50 years (SD,16) and 1097 (53.1%) were male. A total of 177 patients showed high CAC level, and compared with patients with low CAC, these patients were older (mean age: 49 vs. 69 years, P |
| Databáze: | OpenAIRE |
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