N-Terminal Fragment of Brain-Type Natriuretic Peptide (NT-proBNP) as a Prognostic Marker in Patients with Newly Diagnosed Multiple Myeloma Complicated by Dialysis-Dependent Renal Failure
| Autor: | S V Semochkin, E. I. Zhelnova, N. A. Aref’eva, D. O. Sinyavkin, K. V. Yatskov, O. N. Kotenko, E.N. Misyurina, M.A. Lysenko, I. V. Samsonova, D. E. Gagloeva, E A Baryakh, T. N. Tolstykh, E. V. Yurova, A. I. Ushakova |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty medicine.drug_class medicine.medical_treatment Prohormone Renal function Gastroenterology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Renal Dialysis Internal medicine Natriuretic Peptide Brain Natriuretic peptide medicine Humans Prospective Studies Renal Insufficiency Prospective cohort study Dialysis Multiple myeloma Aged Kidney Chemotherapy business.industry General Medicine Middle Aged Prognosis medicine.disease Peptide Fragments 030104 developmental biology medicine.anatomical_structure Female Multiple Myeloma business Biomarkers 030217 neurology & neurosurgery Glomerular Filtration Rate medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 167:267-271 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-019-04506-z |
| Popis: | Prognostic value of N-terminal fragment of the prohormone brain-type natriuretic peptide (NT-proBNP) was analyzed in patients with multiple myeloma complicated by dialysisdependent renal failure. The prospective study included 20 patients with newly diagnosed multiple myeloma. The concentrations of NT-proBNP were measured before antimyeloma chemotherapy. The median age of the patients was 67 (63-76) years. The median glomerular filtration rate was 4 (4, 5) ml/min/1.73 m2. For overall survival, the area under ROC curve was 0.75 and the cut-off point was 7000 pg/ml. At median follow-up of 17.3 months, the overall survival was 76.6±14.8 and 27.3±13.4% (p=0.02) for cases with NT-proBNP levels below and above the cut-off point, respectively. There were no cases of death due to cardiovascular causes. We concluded that the increase in serum concentration of NT-proBNP>7400 pg/ml is associated with the severity of kidney damage and the risk of non-cardiac mortality. |
| Databáze: | OpenAIRE |
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